WNK1
Gene Ontology Biological Process
Gene Ontology Molecular Function
WNK2
Gene Ontology Biological Process
- intracellular signal transduction [ISS]
- negative regulation of ERK1 and ERK2 cascade [IMP]
- negative regulation of cell proliferation [IMP]
- positive regulation of sodium ion transmembrane transporter activity [IMP]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA]
- regulation of ion homeostasis [IMP]
Gene Ontology Molecular Function
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A human MAP kinase interactome.
Mitogen-activated protein kinase (MAPK) pathways form the backbone of signal transduction in the mammalian cell. Here we applied a systematic experimental and computational approach to map 2,269 interactions between human MAPK-related proteins and other cellular machinery and to assemble these data into functional modules. Multiple lines of evidence including conservation with yeast supported a core network of 641 interactions. Using ... [more]
Throughput
- High Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
WNK1 WNK2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 3375203 | |
WNK1 WNK2 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | 0.0117 | BioGRID | 3584744 |
Curated By
- BioGRID