CHTOP
Gene Ontology Molecular Function
PRMT1
Gene Ontology Biological Process
- histone H4-R3 methylation [IBA, ISO]
- histone methylation [IDA, ISO]
- in utero embryonic development [IMP]
- negative regulation of megakaryocyte differentiation [ISO]
- neuron projection development [ISO]
- peptidyl-arginine N-methylation [IDA]
- peptidyl-arginine methylation [ISO]
- peptidyl-arginine methylation, to asymmetrical-dimethyl arginine [IBA, ISO]
- peptidyl-arginine omega-N-methylation [ISO]
- protein methylation [IMP, ISO]
- regulation of transcription, DNA-templated [IBA]
Gene Ontology Molecular Function- N-methyltransferase activity [ISO]
- [cytochrome c]-arginine N-methyltransferase activity [ISO]
- histone methyltransferase activity [IDA, ISO]
- histone methyltransferase activity (H4-R3 specific) [IBA, ISO]
- histone-arginine N-methyltransferase activity [ISO]
- identical protein binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein methyltransferase activity [IMP, ISO]
- protein-arginine N-methyltransferase activity [IDA, ISO]
- protein-arginine omega-N asymmetric methyltransferase activity [IBA, ISO]
- protein-arginine omega-N monomethyltransferase activity [ISO]
- snoRNP binding [ISO]
- N-methyltransferase activity [ISO]
- [cytochrome c]-arginine N-methyltransferase activity [ISO]
- histone methyltransferase activity [IDA, ISO]
- histone methyltransferase activity (H4-R3 specific) [IBA, ISO]
- histone-arginine N-methyltransferase activity [ISO]
- identical protein binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein methyltransferase activity [IMP, ISO]
- protein-arginine N-methyltransferase activity [IDA, ISO]
- protein-arginine omega-N asymmetric methyltransferase activity [IBA, ISO]
- protein-arginine omega-N monomethyltransferase activity [ISO]
- snoRNP binding [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Friend of Prmt1, a novel chromatin target of protein arginine methyltransferases.
We describe the isolation and characterization of Friend of Prmt1 (Fop), a novel chromatin target of protein arginine methyltransferases. Human Fop is encoded by C1orf77, a gene of previously unknown function. We show that Fop is tightly associated with chromatin, and that it is modified by both asymmetric and symmetric arginine methylation in vivo. Furthermore, Fop plays an important role ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PRMT1 CHTOP | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - | |
| PRMT1 CHTOP | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 465244 |
Curated By
- BioGRID