BAIT
GATA3
HDR, HDRS
GATA binding protein 3
GO Process (58)
GO Function (13)
GO Component (4)
Gene Ontology Biological Process
- T cell receptor signaling pathway [ISS]
- TOR signaling [ISS]
- anatomical structure formation involved in morphogenesis [ISS]
- anatomical structure morphogenesis [TAS]
- aortic valve morphogenesis [ISS]
- blood coagulation [TAS]
- canonical Wnt signaling pathway involved in metanephric kidney development [ISS]
- cardiac right ventricle morphogenesis [ISS]
- cell fate determination [ISS]
- cellular response to interferon-alpha [IEP]
- cellular response to interleukin-4 [IEP]
- cellular response to tumor necrosis factor [IEP]
- defense response [TAS]
- ear development [IMP]
- kidney development [IMP]
- lymphocyte migration [IDA]
- male gonad development [ISS]
- mesenchymal to epithelial transition [IDA]
- mesonephros development [ISS]
- negative regulation of cell cycle [IMP]
- negative regulation of cell motility [IMP]
- negative regulation of cell proliferation [ISS]
- negative regulation of cell proliferation involved in mesonephros development [ISS]
- negative regulation of endothelial cell apoptotic process [IMP]
- negative regulation of fat cell differentiation [IMP]
- negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation [ISS]
- negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation [ISS]
- negative regulation of inflammatory response [IMP]
- negative regulation of mammary gland epithelial cell proliferation [IDA]
- negative regulation of transcription, DNA-templated [IMP]
- nephric duct formation [ISS]
- nephric duct morphogenesis [ISS]
- norepinephrine biosynthetic process [ISS]
- pharyngeal system development [ISS]
- phosphatidylinositol 3-kinase signaling [ISS]
- positive regulation of T cell differentiation [ISS]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of interleukin-13 secretion [IDA, IMP]
- positive regulation of interleukin-4 production [ISS]
- positive regulation of interleukin-5 secretion [IDA]
- positive regulation of protein kinase B signaling [IMP]
- positive regulation of signal transduction [IMP]
- positive regulation of thyroid hormone generation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISS]
- positive regulation of transcription regulatory region DNA binding [IMP]
- positive regulation of transcription, DNA-templated [IDA, IMP, ISS]
- positive regulation of ureteric bud formation [ISS]
- regulation of cellular response to X-ray [IMP]
- regulation of cytokine biosynthetic process [ISS]
- regulation of nephron tubule epithelial cell differentiation [ISS]
- response to estrogen [IEP]
- response to virus [IEP]
- signal transduction [ISS]
- sympathetic nervous system development [ISS]
- transcription from RNA polymerase II promoter [TAS]
- ureteric bud formation [ISS]
- uterus development [ISS]
- ventricular septum development [ISS]
Gene Ontology Molecular Function- DNA binding [TAS]
- E-box binding [IDA]
- HMG box domain binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IMP]
- core promoter proximal region sequence-specific DNA binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- nucleic acid binding transcription factor activity [IDA, IMP]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- transcription regulatory region sequence-specific DNA binding [IDA]
- DNA binding [TAS]
- E-box binding [IDA]
- HMG box domain binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IMP]
- core promoter proximal region sequence-specific DNA binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- nucleic acid binding transcription factor activity [IDA, IMP]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- transcription regulatory region sequence-specific DNA binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
MDM2
ACTFS, HDMX, hdm2
MDM2 proto-oncogene, E3 ubiquitin protein ligase
GO Process (25)
GO Function (7)
GO Component (9)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [IMP, TAS]
- Fc-epsilon receptor signaling pathway [TAS]
- cellular response to hypoxia [IEP]
- epidermal growth factor receptor signaling pathway [TAS]
- establishment of protein localization [IDA]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [IDA]
- negative regulation of cell cycle arrest [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-lysine modification [IMP]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of cell proliferation [TAS]
- positive regulation of mitotic cell cycle [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA]
- protein complex assembly [IDA]
- protein destabilization [IDA]
- protein localization to nucleus [IDA]
- protein ubiquitination [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA]
- regulation of protein catabolic process [IDA]
- response to antibiotic [IEP]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Ras-ERK MAPK cascade regulates GATA3 stability and Th2 differentiation through ubiquitin-proteasome pathway.
Differentiation of naive CD4 T cells into Th2 cells requires protein expression of GATA3. Interleukin-4 induces STAT6 activation and subsequent GATA3 transcription. Little is known, however, on how T cell receptor-mediated signaling regulates GATA3 and Th2 cell differentiation. Here we demonstrated that T cell receptor-mediated activation of the Ras-ERK MAPK cascade stabilizes GATA3 protein in developing Th2 cells through the ... [more]
J. Biol. Chem. Aug. 19, 2005; 280(33);29409-19 [Pubmed: 15975924]
Throughput
- Low Throughput
Curated By
- BioGRID