SKP2
Gene Ontology Biological Process
Gene Ontology Molecular Function
RAG2
Gene Ontology Biological Process
Gene Ontology Molecular Function- chromatin binding [ISS]
- methylated histone binding [ISS]
- phosphatidylinositol binding [ISS]
- phosphatidylinositol-3,4,5-trisphosphate binding [ISS]
- phosphatidylinositol-3,4-bisphosphate binding [ISS]
- phosphatidylinositol-3,5-bisphosphate binding [ISS]
- phosphatidylinositol-4,5-bisphosphate binding [ISS]
- zinc ion binding [ISS]
- chromatin binding [ISS]
- methylated histone binding [ISS]
- phosphatidylinositol binding [ISS]
- phosphatidylinositol-3,4,5-trisphosphate binding [ISS]
- phosphatidylinositol-3,4-bisphosphate binding [ISS]
- phosphatidylinositol-3,5-bisphosphate binding [ISS]
- phosphatidylinositol-4,5-bisphosphate binding [ISS]
- zinc ion binding [ISS]
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
Ubiquitylation of RAG-2 by Skp2-SCF links destruction of the V(D)J recombinase to the cell cycle.
The periodic destruction of RAG-2 at the G1-to-S transition couples V(D)J recombination to the G0 and G1 cell cycle phases and coordinates RAG-mediated DNA cleavage with DNA repair by nonhomologous end joining. To define the mechanism by which this occurs, we reproduced cell cycle-dependent regulation of the V(D)J recombinase in a cell-free system. The ubiquitin-proteasomal pathway carries out destruction of ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SKP2 RAG2 | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 1067173 |
Curated By
- BioGRID