BAIT

LET-756

CELE_C05D11.4, C05D11.4

let-756 encodes an fibroblast growth factor (FGF)-like ligand that is required for progression through early larval development; LET-756 is expressed from late embryogenesis to adulthood, with a peak of expression in larvae; with EGL-17, LET-756 is redundantly required to activate EGL-15/FGFR, which in turn activates protein degradation in adult muscle cells; homozygotes for partial loss-of-function alleles are small, clear, and scrawny, but viable, while those for a null allele arrest in early larval development.

GO Process (4)

GO Function (5)

GO Component (6)

Gene Ontology Biological Process

fibroblast growth factor receptor signaling pathway [IMP]

negative regulation of cell projection organization [IMP]

nematode larval development [IMP]

regulation of axon extension involved in axon guidance [IMP]

Gene Ontology Molecular Function

fibroblast growth factor receptor binding [ISS]
growth factor activity [IMP]
protein binding [IPI]
protein kinase binding [IPI]
transcription factor binding [IPI]

Gene Ontology Cellular Component

U1 snRNP [IDA]

cytoplasm [IDA]

extracellular region [IDA]

nuclear speck [IDA]

nucleolus [IDA]

nucleus [IDA]

WormBase Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Caenorhabditis elegans

PREY

CKB-3

CELE_B0285.10, B0285.10

ckb-3 encodes a putative choline kinase; CKB-1 through CKB-4 comprise a related group ('B') of choline kinases.

GO Process (0)

GO Function (0)

GO Component (0)

WormBase Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Caenorhabditis elegans

Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

Publication

A global analysis of genetic interactions in Caenorhabditis elegans.

Byrne AB, Weirauch MT, Wong V, Koeva M, Dixon SJ, Stuart JM, Roy PJ

BACKGROUND: Understanding gene function and genetic relationships is fundamental to our efforts to better understand biological systems. Previous studies systematically describing genetic interactions on a global scale have either focused on core biological processes in protozoans or surveyed catastrophic interactions in metazoans. Here, we describe a reliable high-throughput approach capable of revealing both weak and strong genetic interactions in the ... [more]

J. Biol. Sep. 28, 2007; 6(3);8 [Pubmed: 17897480]

Quantitative Score

3.8 [SGA Score]

Throughput

High Throughput

Ontology Terms

phenotype: organism development variant (WBPHENOTYPE:0000531)

Additional Notes

A systematic genetic interaction analysis (SGI) was carried out to detect interactions between 11 query mutants and 858 target genes compromised by RNA interference (RNAi). Interactions were determined using growth scores that indicated whether the resulting number of progeny from the double mutant was significantly different than that of single mutant controls.
Negative Genetic

Curated By

BioGRID

Interaction Summary