BAIT
BAR-1
CELE_C54D1.6, pvl-1, spy-1, C54D1.6
bar-1 encodes a beta-catenin; during C. elegans development, BAR-1 likely functions as a transcriptional coactivator whose activity is required for Q neuroblast migration, P12 cell fate specification, and P3.p through P8.p vulval cell fate specification at two different stages of development; in specifying vulval cell fates, bar-1 interacts with Wnt and MAPK signaling pathways to regulate proper expression of the LIN-39 homeodomain transcription factor, overexpresion of which can partially rescue the bar-1 mutant phenotype; in yeast two-hybrid assays, BAR-1 interacts strongly with the POP-1/TCF transcription factor, and when fused to the Gal4 DNA binding domain, BAR-1 can function in yeast as a transcriptional coactivator; during larval development, BAR-1 expression begins in P3.p through P8.p at the late L1 stage and then disappears from these cells by the mid-L3 stage; BAR-1 is also expressed in P12, in the seam cells, and in cells of the somatic gonad; BAR-1 subcellular localization, assessed using an integrated transgene, reveals localization to the cytoplasm, nucleus, and cell junctions; genetic mosaic analyses indicate that, in P4.p and in P12, bar-1 acts cell autonomously to specify cell fates.
GO Process (16)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
- Ras protein signal transduction [IGI]
- Wnt signaling pathway [IMP]
- cell adhesion [TAS]
- cell fate specification [IMP]
- hermaphrodite genitalia development [IMP]
- locomotion [IMP]
- mating behavior [IMP]
- morphogenesis of an epithelium [IMP]
- oviposition [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of vulval development [IMP]
- receptor-mediated endocytosis [IMP]
- regulation of backward locomotion [IMP]
- regulation of cell fate specification [IMP]
- regulation of cell migration [IMP]
- regulation of vulval development [IGI, IMP]
Gene Ontology Molecular Function
Caenorhabditis elegans
PREY
SMA-6
CELE_C32D5.2, C32D5.2
sma-6 encodes a serine/threonine protein kinase that is orthologous to type I TGF-beta receptors; sma-6 activity is required for regulating body length and for proper development of the male tail; sma-6, along with other genes in the TGF-beta Sma/Mab pathway, also regulates reproductive aging; a reduction of TGF-beta pathway genes extends reproductive span by maintaining oocyte and germline quality; sma-6 expression first begins at the 1.5-fold stage of embryogenesis and continues through adulthood; sma-6 is expressed in dorsal and ventral hypodermis, pharyngeal muscle, and the intestine; expression in the hypodermis is necessary and sufficient for body length regulation.
GO Process (13)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- BMP signaling pathway [ISS]
- body morphogenesis [IMP]
- dauer larval development [IGI]
- defense response to fungus [IMP]
- innate immune response [IMP]
- maintenance of protein location in nucleus [IMP]
- nematode male tail tip morphogenesis [IGI, IMP]
- positive regulation of multicellular organism growth [IGI, IMP]
- positive regulation of protein catabolic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of cell adhesion [IMP]
- regulation of cell morphogenesis [IMP]
- reproduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Caenorhabditis elegans
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
A global analysis of genetic interactions in Caenorhabditis elegans.
BACKGROUND: Understanding gene function and genetic relationships is fundamental to our efforts to better understand biological systems. Previous studies systematically describing genetic interactions on a global scale have either focused on core biological processes in protozoans or surveyed catastrophic interactions in metazoans. Here, we describe a reliable high-throughput approach capable of revealing both weak and strong genetic interactions in the ... [more]
J. Biol. Sep. 28, 2007; 6(3);8 [Pubmed: 17897480]
Quantitative Score
- 1.6 [SGA Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: organism development variant (WBPHENOTYPE:0000531)
Additional Notes
- A systematic genetic interaction analysis (SGI) was carried out to detect interactions between 11 query mutants and 858 target genes compromised by RNA interference (RNAi). Interactions were determined using growth scores that indicated whether the resulting number of progeny from the double mutant was significantly different than that of single mutant controls.
- Negative Genetic
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SMA-6 BAR-1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | 3.25 | BioGRID | 466276 |
Curated By
- BioGRID