BAIT
EGL-15
CELE_F58A3.2
Protein EGL-15
GO Process (17)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
- axon guidance [IMP]
- cell migration [IMP]
- digestive tract morphogenesis [IMP]
- embryo development ending in birth or egg hatching [IMP]
- engulfment of apoptotic cell [IMP]
- fibroblast growth factor receptor signaling pathway [IMP]
- hermaphrodite genitalia development [IMP]
- locomotion [IMP]
- muscle organ development [IMP]
- nematode larval development [IMP]
- oviposition [IMP]
- protein catabolic process [IMP]
- protein phosphorylation [IDA]
- receptor-mediated endocytosis [IMP]
- regulation of cell projection organization [IMP]
- reproduction [IMP]
- secretion by cell [IMP]
Gene Ontology Molecular Function
Caenorhabditis elegans
PREY
MEL-28
CELE_C38D4.3, C38D4.3
mel-28 encodes a large (1,784-residue) protein required for nuclear envelope assembly; MEL-28 is highly divergent from, but orthologous to human AT-hook-containing transcription factor 1 (AHCTF1); MEL-28 is found in nuclear pore complexes (NPCs) during interphase, kinetochores early in mitosis, and chromatin later in mitosis; mel-28 mutants were first identified in a screen for genes involved in cell division in the early embryo; mel-28 mutants or mel-28(RNAi) animals have no (or poorly visible) pronuclei and nuclear morphology generally, along with a weak mitotic spindle, aberrant chromatin segregation, and abnormally distributed nuclear envelope (NE) proteins and NPCs; MEL-28 is needed for normal localization of LMN-1 and EMR-1, and appears to be a stable structural component of the NE; maternal MEL-28 is needed for embryonic development.
GO Process (5)
GO Function (0)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Caenorhabditis elegans
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
A global analysis of genetic interactions in Caenorhabditis elegans.
BACKGROUND: Understanding gene function and genetic relationships is fundamental to our efforts to better understand biological systems. Previous studies systematically describing genetic interactions on a global scale have either focused on core biological processes in protozoans or surveyed catastrophic interactions in metazoans. Here, we describe a reliable high-throughput approach capable of revealing both weak and strong genetic interactions in the ... [more]
J. Biol. Sep. 28, 2007; 6(3);8 [Pubmed: 17897480]
Quantitative Score
- 2.6 [SGA Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: organism development variant (WBPHENOTYPE:0000531)
Additional Notes
- A systematic genetic interaction analysis (SGI) was carried out to detect interactions between 11 query mutants and 858 target genes compromised by RNA interference (RNAi). Interactions were determined using growth scores that indicated whether the resulting number of progeny from the double mutant was significantly different than that of single mutant controls.
- Negative Genetic
Curated By
- BioGRID