BAIT
LET-756
CELE_C05D11.4, C05D11.4
let-756 encodes an fibroblast growth factor (FGF)-like ligand that is required for progression through early larval development; LET-756 is expressed from late embryogenesis to adulthood, with a peak of expression in larvae; with EGL-17, LET-756 is redundantly required to activate EGL-15/FGFR, which in turn activates protein degradation in adult muscle cells; homozygotes for partial loss-of-function alleles are small, clear, and scrawny, but viable, while those for a null allele arrest in early larval development.
GO Process (4)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Caenorhabditis elegans
PREY
HDA-1
CELE_C53A5.3, gon-10, C53A5.3
The hda-1 gene encodes a histone deacetylase 1, similar to histone deacetylases RPD3 from yeast and fly; maternal and zygotic expression of hda-1 is required for embryonic viability, and zygotic expression of hda-1 is also required for gonadogenesis and vulval development.
GO Process (16)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- apoptotic process [IMP]
- embryo development ending in birth or egg hatching [IMP]
- embryonic digestive tract morphogenesis [IGI]
- gonad development [IMP]
- hermaphrodite genitalia development [IMP]
- histone deacetylation [IDA]
- negative regulation of Notch signaling pathway [IMP]
- negative regulation of Ras protein signal transduction [IGI]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of vulval development [IGI, IMP]
- nematode larval development [IMP]
- nematode male tail tip morphogenesis [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- receptor-mediated endocytosis [IMP]
- regulation of cell differentiation [IGI]
- reproduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Caenorhabditis elegans
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
A global analysis of genetic interactions in Caenorhabditis elegans.
BACKGROUND: Understanding gene function and genetic relationships is fundamental to our efforts to better understand biological systems. Previous studies systematically describing genetic interactions on a global scale have either focused on core biological processes in protozoans or surveyed catastrophic interactions in metazoans. Here, we describe a reliable high-throughput approach capable of revealing both weak and strong genetic interactions in the ... [more]
J. Biol. Sep. 28, 2007; 6(3);8 [Pubmed: 17897480]
Quantitative Score
- 5.0833 [SGA Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: organism development variant (WBPHENOTYPE:0000531)
Additional Notes
- A systematic genetic interaction analysis (SGI) was carried out to detect interactions between 11 query mutants and 858 target genes compromised by RNA interference (RNAi). Interactions were determined using growth scores that indicated whether the resulting number of progeny from the double mutant was significantly different than that of single mutant controls.
- Negative Genetic
Curated By
- BioGRID