BAIT
EGL-15
CELE_F58A3.2
Protein EGL-15
GO Process (17)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
- axon guidance [IMP]
- cell migration [IMP]
- digestive tract morphogenesis [IMP]
- embryo development ending in birth or egg hatching [IMP]
- engulfment of apoptotic cell [IMP]
- fibroblast growth factor receptor signaling pathway [IMP]
- hermaphrodite genitalia development [IMP]
- locomotion [IMP]
- muscle organ development [IMP]
- nematode larval development [IMP]
- oviposition [IMP]
- protein catabolic process [IMP]
- protein phosphorylation [IDA]
- receptor-mediated endocytosis [IMP]
- regulation of cell projection organization [IMP]
- reproduction [IMP]
- secretion by cell [IMP]
Gene Ontology Molecular Function
Caenorhabditis elegans
PREY
LRP-1
CELE_F29D11.1, egf-4, F29D11.1
lrp-1 encodes a low-density lipoprotein (LDL) receptor-like protein most closely related to the vertebrate gp330/megalin/LRP-2 proteins; during development, lrp-1 activity is required in the hyp7 syncytium for completion of molting and for growth beyond the third larval stage; LRP-1 is expressed on the apical surface of the hyp6 and hyp7 syncytia in hermaphrodites and males from hatching through adulthood; as sterol starvation mimics the lrp-1 mutant phenotype, LRP-1 is likely to function as a receptor for sterols normally endocytosed by the hyp7 syncytium.
GO Process (12)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- body morphogenesis [IMP]
- cell migration [IMP]
- ecdysis, collagen and cuticulin-based cuticle [IMP]
- growth [IMP]
- locomotion [IMP]
- molting cycle, collagen and cuticulin-based cuticle [IMP]
- nematode larval development [IMP]
- positive regulation of locomotion [IMP]
- positive regulation of multicellular organism growth [IMP]
- regulation of cell migration [IGI]
- secretion by cell [IMP]
- sterol transport [IMP, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Caenorhabditis elegans
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
A global analysis of genetic interactions in Caenorhabditis elegans.
BACKGROUND: Understanding gene function and genetic relationships is fundamental to our efforts to better understand biological systems. Previous studies systematically describing genetic interactions on a global scale have either focused on core biological processes in protozoans or surveyed catastrophic interactions in metazoans. Here, we describe a reliable high-throughput approach capable of revealing both weak and strong genetic interactions in the ... [more]
J. Biol. Sep. 28, 2007; 6(3);8 [Pubmed: 17897480]
Quantitative Score
- 4.8333 [SGA Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: organism development variant (WBPHENOTYPE:0000531)
Additional Notes
- A systematic genetic interaction analysis (SGI) was carried out to detect interactions between 11 query mutants and 858 target genes compromised by RNA interference (RNAi). Interactions were determined using growth scores that indicated whether the resulting number of progeny from the double mutant was significantly different than that of single mutant controls.
- Negative Genetic
Curated By
- BioGRID