BAIT
SOS-1
CELE_T28F12.3, let-341, T28F12.3
sos-1 encodes an ortholog of Son of sevenless, a guanine nucleotide exchange factor; sos-1 is required for viability, sex myoblast migration, vulval induction, and oogenesis; sos-1 acts genetically downstream of let-23 and upstream of let-60 with respect to vulval development; SOS-1 binds bovine calmodulin in vitro in a calcium-dependent manner.
GO Process (10)
GO Function (2)
GO Component (0)
Gene Ontology Biological Process
- body morphogenesis [IMP]
- cell migration [IMP]
- embryo development [IMP]
- embryo development ending in birth or egg hatching [IMP]
- female gamete generation [IMP]
- oviposition [IMP]
- positive regulation of Ras GTPase activity [ISS]
- positive regulation of vulval development [IGI]
- reproduction [IMP]
- secretion by cell [IMP]
Gene Ontology Molecular Function
Caenorhabditis elegans
PREY
MOM-2
CELE_F38E1.7, F38E1.7
mom-2 encodes a member of the Wnt family of secreted signaling glycoproteins that is required for induction of endodermal (gut) tissue in the 4-cell stage embryo; MOM-2, required in the inducing blastomere (P2) at the 4-cell stage, may be the ligand for MOM-5, a Frizzled homolog, thought to act in the receiving blastomere (EMS); MOM-2 genetically interacts in the same pathway as KIN-19, but parallel to APR-1; MOM-2 also may be a ligand for LIN-18, a Ryk homolog.
GO Process (12)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- RNA interference [IMP]
- Wnt signaling pathway [IBA, ISS]
- asymmetric protein localization involved in cell fate determination [IMP]
- body morphogenesis [IMP]
- embryo development ending in birth or egg hatching [IMP]
- embryonic morphogenesis [IMP]
- endodermal cell fate specification [IGI, IMP]
- establishment of cell polarity [IMP]
- establishment of mitotic spindle orientation [IGI, IMP]
- nematode larval development [IMP]
- neuron differentiation [IBA]
- reproduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Caenorhabditis elegans
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
A global analysis of genetic interactions in Caenorhabditis elegans.
BACKGROUND: Understanding gene function and genetic relationships is fundamental to our efforts to better understand biological systems. Previous studies systematically describing genetic interactions on a global scale have either focused on core biological processes in protozoans or surveyed catastrophic interactions in metazoans. Here, we describe a reliable high-throughput approach capable of revealing both weak and strong genetic interactions in the ... [more]
J. Biol. Sep. 28, 2007; 6(3);8 [Pubmed: 17897480]
Quantitative Score
- 4.1429 [SGA Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: organism development variant (WBPHENOTYPE:0000531)
Additional Notes
- A systematic genetic interaction analysis (SGI) was carried out to detect interactions between 11 query mutants and 858 target genes compromised by RNA interference (RNAi). Interactions were determined using growth scores that indicated whether the resulting number of progeny from the double mutant was significantly different than that of single mutant controls.
- Negative Genetic
Curated By
- BioGRID