BAIT
EGL-15
CELE_F58A3.2
Protein EGL-15
GO Process (17)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
- axon guidance [IMP]
- cell migration [IMP]
- digestive tract morphogenesis [IMP]
- embryo development ending in birth or egg hatching [IMP]
- engulfment of apoptotic cell [IMP]
- fibroblast growth factor receptor signaling pathway [IMP]
- hermaphrodite genitalia development [IMP]
- locomotion [IMP]
- muscle organ development [IMP]
- nematode larval development [IMP]
- oviposition [IMP]
- protein catabolic process [IMP]
- protein phosphorylation [IDA]
- receptor-mediated endocytosis [IMP]
- regulation of cell projection organization [IMP]
- reproduction [IMP]
- secretion by cell [IMP]
Gene Ontology Molecular Function
Caenorhabditis elegans
PREY
SNFC-5
CELE_R07E5.3, swsn-5, R07E5.3
snfc-5 encodes a homolog of SNF5/Ini1, a component of the SWI/SNF complex that is conserved from yeast to mammals and that is involved in chromatin remodeling; snfc-5 may be involved in asymmetric cell division of the T cells.
GO Process (14)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
- ATP-dependent chromatin remodeling [IBA]
- DNA repair [IBA]
- apoptotic process [IMP]
- cell differentiation [IBA]
- embryo development ending in birth or egg hatching [IMP]
- hermaphrodite genitalia development [IMP]
- mitotic cell cycle phase transition [IBA]
- negative regulation of cell proliferation [IBA]
- nematode larval development [IMP]
- nucleosome disassembly [IBA]
- oviposition [IMP]
- receptor-mediated endocytosis [IMP]
- regulation of transcription from RNA polymerase II promoter [IBA]
- reproduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Caenorhabditis elegans
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
A global analysis of genetic interactions in Caenorhabditis elegans.
BACKGROUND: Understanding gene function and genetic relationships is fundamental to our efforts to better understand biological systems. Previous studies systematically describing genetic interactions on a global scale have either focused on core biological processes in protozoans or surveyed catastrophic interactions in metazoans. Here, we describe a reliable high-throughput approach capable of revealing both weak and strong genetic interactions in the ... [more]
J. Biol. Sep. 28, 2007; 6(3);8 [Pubmed: 17897480]
Quantitative Score
- 4.6667 [SGA Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: organism development variant (WBPHENOTYPE:0000531)
Additional Notes
- A systematic genetic interaction analysis (SGI) was carried out to detect interactions between 11 query mutants and 858 target genes compromised by RNA interference (RNAi). Interactions were determined using growth scores that indicated whether the resulting number of progeny from the double mutant was significantly different than that of single mutant controls.
- Negative Genetic
Curated By
- BioGRID