BAIT

LET-23

CELE_ZK1067.1
Protein LET-23
Caenorhabditis elegans
PREY

SCD-2

CELE_T10H9.2, T10H9.2
scd-2 encodes the homolog of the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase (RTK) (OMIM:105590, involved in the development of non-Hodgkin's lymphoma in humans); the ALK family of receptor tyrosine kinases belong to the insulin receptor superfamily; scd-2 was initially identified in a naturally occuring desert oasis strain of C. elegans that fails to respond to the dauer pheromone at 25 degrees centigrade, but does so at a higher temperature; genetic interactions of scd-2 with several genes in the TGF-beta pathway including daf-7, daf-8 and daf-4 indicate that scd-2 acts in parallel to or converges with this pathway to regulate dauer formation via activation of the daf-3 transcription factor; further, genetic interaction studies indicate that the genes hen-1 (ortholog of the ALK ligand), soc-1 (RTK multi-adaptor protein related to DOS/Gab) and sma-5 (similar to human ERK5/MAP kinase 7) act along with scd-2 RTK in a chemosensory transduction pathway that converges with the TGF-beta pathway to affect the dauer decision.
GO Process (1)
GO Function (0)
GO Component (0)

Gene Ontology Biological Process

Caenorhabditis elegans

Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

Publication

A global analysis of genetic interactions in Caenorhabditis elegans.

Byrne AB, Weirauch MT, Wong V, Koeva M, Dixon SJ, Stuart JM, Roy PJ

BACKGROUND: Understanding gene function and genetic relationships is fundamental to our efforts to better understand biological systems. Previous studies systematically describing genetic interactions on a global scale have either focused on core biological processes in protozoans or surveyed catastrophic interactions in metazoans. Here, we describe a reliable high-throughput approach capable of revealing both weak and strong genetic interactions in the ... [more]

J. Biol. Sep. 28, 2007; 6(3);8 [Pubmed: 17897480]

Quantitative Score

  • 3.5 [SGA Score]

Throughput

  • High Throughput

Ontology Terms

  • phenotype: organism development variant (WBPHENOTYPE:0000531)

Additional Notes

  • A systematic genetic interaction analysis (SGI) was carried out to detect interactions between 11 query mutants and 858 target genes compromised by RNA interference (RNAi). Interactions were determined using growth scores that indicated whether the resulting number of progeny from the double mutant was significantly different than that of single mutant controls.
  • Negative Genetic

Curated By

  • BioGRID