BAIT
DAF-2
CELE_Y55D5A.5
Protein DAF-2
GO Process (16)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- dauer entry [IMP]
- dauer exit [IMP]
- dauer larval development [IMP]
- determination of adult lifespan [IGI, IMP]
- gamete generation [IMP]
- insulin receptor signaling pathway [ISS]
- lipid storage [IMP]
- locomotion [IMP]
- negative regulation of transcription factor import into nucleus [IGI, IMP]
- positive regulation of multicellular organism growth [IMP]
- protein autophosphorylation [ISS]
- regulation of autophagic vacuole assembly [IMP]
- regulation of development, heterochronic [IGI]
- regulation of response to reactive oxygen species [IMP]
- reproduction [IMP]
- response to heat [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Caenorhabditis elegans
PREY
SMA-2
CELE_ZK370.2, cem-1, ZK370.2
sma-2 encodes, along with sma-3 and sma-4, one of three C. elegans Smad proteins, with SMA-2 and SMA-3 most closely related to receptor-regulated Smads (R-Smads) and SMA-4 more closely related to co-mediator Smads (CoSmads); during development, SMA-2 functions in a TGF-beta signaling pathway to regulate body size and specification of sensory structures in the male tail; sma-2, through this pathway, also regulates reproductive aging; studies show that reduction of TGF-beta pathway genes extends reproductive span by maintaining oocyte and germline quality; a sma-2::gfp reporter is expressed in the pharynx, intestine, and hypodermis.
GO Process (3)
GO Function (0)
GO Component (0)
Gene Ontology Biological Process
Caenorhabditis elegans
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
A global analysis of genetic interactions in Caenorhabditis elegans.
BACKGROUND: Understanding gene function and genetic relationships is fundamental to our efforts to better understand biological systems. Previous studies systematically describing genetic interactions on a global scale have either focused on core biological processes in protozoans or surveyed catastrophic interactions in metazoans. Here, we describe a reliable high-throughput approach capable of revealing both weak and strong genetic interactions in the ... [more]
J. Biol. Sep. 28, 2007; 6(3);8 [Pubmed: 17897480]
Quantitative Score
- 3.2 [SGA Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: organism development variant (WBPHENOTYPE:0000531)
Additional Notes
- A systematic genetic interaction analysis (SGI) was carried out to detect interactions between 11 query mutants and 858 target genes compromised by RNA interference (RNAi). Interactions were determined using growth scores that indicated whether the resulting number of progeny from the double mutant was significantly different than that of single mutant controls.
- Negative Genetic
Curated By
- BioGRID