LET-23
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
LIN-3
Gene Ontology Biological Process
- epidermal growth factor receptor signaling pathway [IGI, ISS]
- inductive cell-cell signaling [IMP]
- locomotion [IMP]
- male genitalia development [IMP]
- negative regulation of vulval development [IMP]
- nematode larval development [IMP]
- oviposition [IMP]
- ovulation [IMP]
- positive regulation of vulval development [IMP]
- post-embryonic development [IMP]
- regulation of cell fate specification [IMP]
- reproduction [IMP]
- vulval development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways.
Most heritable traits, including disease susceptibility, are affected by interactions between multiple genes. However, we understand little about how genes interact because very few possible genetic interactions have been explored experimentally. We have used RNA interference in Caenorhabditis elegans to systematically test approximately 65,000 pairs of genes for their ability to interact genetically. We identify approximately 350 genetic interactions between ... [more]
Throughput
- High Throughput
Ontology Terms
- phenotype: sterile (WBPHENOTYPE:0000688)
Additional Notes
- A large-scale genetic interaction analysis was carried out to detect interactions between 37 query mutants and approximately 1,750 target genes compromised by RNA interference (RNAi). Interactions were identified if the phenotype of the combined query-target perturbation was greater than the sum of the two individual perturbations.
- Synthetic
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| LIN-3 LET-23 | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | WormBase | 2835998 | |
| LET-23 LIN-3 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | 3.1875 | BioGRID | 466475 | |
| LET-23 LIN-3 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | WormBase | - |
Curated By
- BioGRID