Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways.

Lehner B, Crombie C, Tischler J, Fortunato A, Fraser AG

Most heritable traits, including disease susceptibility, are affected by interactions between multiple genes. However, we understand little about how genes interact because very few possible genetic interactions have been explored experimentally. We have used RNA interference in Caenorhabditis elegans to systematically test approximately 65,000 pairs of genes for their ability to interact genetically. We identify approximately 350 genetic interactions between ... [more]

Nat. Genet. Aug. 01, 2006; 38(8);896-903 [Pubmed: 16845399]

Throughput

  • High Throughput

Ontology Terms

  • phenotype: embryonic lethal (WBPHENOTYPE:0000050)

Additional Notes

  • A large-scale genetic interaction analysis was carried out to detect interactions between 37 query mutants and approximately 1,750 target genes compromised by RNA interference (RNAi). Interactions were identified if the phenotype of the combined query-target perturbation was greater than the sum of the two individual perturbations.
  • Synthetic

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
LET-23 LIN-40
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High2.8BioGRID
466986

Curated By

  • BioGRID