BAIT
NKX2.2A
id:ibd5090, nk2.2, nkx2-2, nkx2.2, wu:fc83b01, zgc:136536
NK2 homeobox 2a
GO Process (9)
GO Function (0)
GO Component (0)
Gene Ontology Biological Process
- Schwann cell development [IMP]
- endocrine pancreas development [IMP]
- floor plate development [IMP]
- floor plate formation [IMP]
- glial cell migration [IMP]
- motor neuron axon guidance [IMP]
- spinal cord oligodendrocyte cell differentiation [IMP]
- spinal cord oligodendrocyte cell fate specification [IMP]
- ventral spinal cord interneuron differentiation [IGI]
Danio rerio
PREY
NKX2.2B
DKEYP-50F5.3
NK2 homeobox 2b
GO Process (2)
GO Function (0)
GO Component (0)
Gene Ontology Biological Process
Danio rerio
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Regulatory interactions specifying Kolmer-Agduhr interneurons.
In the zebrafish spinal cord, two classes of neurons develop from the lateral floor plate: Kolmer-Agduhr' (KA') and V3 interneurons. We show here that the differentiation of the correct number of KA' cells depends on the activity of the homeobox transcription factor Nkx2.9. This factor acts in concert with Nkx2.2a and Nkx2.2b. These factors are also required for the expression ... [more]
Development Aug. 01, 2010; 137(16);2713-22 [Pubmed: 20610488]
Throughput
- Low Throughput
Additional Notes
- Based on a triple morphant which included nkx2.2a, nkx2.2b, and nkx2.9. The triple mutant has a more severe phenotype than any combination of two of these genes.
- GO:0021514 ventral spinal cord interneuron differentiation
- PATO:0001507 disrupted
Curated By
- BioGRID