BAIT

EHMT2

BAT8, C6orf30, G9A, GAT8, KMT1C, NG36, DAAP-66K18.3
euchromatic histone-lysine N-methyltransferase 2
Cell Cycle - Senescence Project
Parkinson's Disease Project
Homo sapiens
PREY

RELB

I-REL, IREL, REL-B
v-rel avian reticuloendotheliosis viral oncogene homolog B
Cell Cycle - Senescence Project
Human Papilloma Virus (HPV) Project
GO Process (2)
GO Function (3)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Reconstituted Complex

An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.

Publication

The NF-kappaB factor RelB and histone H3 lysine methyltransferase G9a directly interact to generate epigenetic silencing in endotoxin tolerance.

Chen X, El Gazzar M, Yoza BK, McCall CE

The interplay of transcription factors, histone modifiers, and DNA modification can alter chromatin structure that epigenetically controls gene transcription. During severe systemic inflammatory (SSI), the generation of facultative heterochromatin from euchromatin reversibly silences transcription of a set of acute proinflammatory genes. This gene-specific silencing is a salient feature of the endotoxin tolerant phenotype that is found in blood leukocytes of ... [more]

J. Biol. Chem. Oct. 09, 2009; 284(41);27857-65 [Pubmed: 19690169]

Throughput

  • Low Throughput

Additional Notes

  • ChIP

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
EHMT2 RELB
Co-localization
Co-localization

Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.

Low-BioGRID
467899

Curated By

  • BioGRID