BAIT
MRE11A
Mre11, Mre11b, RP23-149D5.3
meiotic recombination 11 homolog A (S. cerevisiae)
GO Process (17)
GO Function (5)
GO Component (9)
Gene Ontology Biological Process
- DNA duplex unwinding [ISO]
- base-excision repair [IBA]
- cell proliferation [IMP]
- cellular response to DNA damage stimulus [ISO]
- chromosome organization [IMP]
- double-strand break repair [IMP]
- intra-S DNA damage checkpoint [IMP]
- mitotic G2 DNA damage checkpoint [IMP]
- negative regulation of DNA endoreduplication [ISO]
- negative regulation of viral entry into host cell [ISO]
- nucleic acid phosphodiester bond hydrolysis [IBA]
- nucleotide-excision repair [IBA]
- positive regulation of kinase activity [ISO]
- positive regulation of protein autophosphorylation [ISO]
- sister chromatid cohesion [ISO]
- synapsis [IMP]
- telomere maintenance [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PRKDC
AI326420, AU019811, DNA-PKcs, DNAPDcs, DNAPK, DNPK1, DOXNPH, HYRC1, XRCC7, dxnph, p460, scid, slip
protein kinase, DNA activated, catalytic polypeptide
GO Process (36)
GO Function (7)
GO Component (7)
Gene Ontology Biological Process
- B cell lineage commitment [IMP]
- T cell differentiation in thymus [IMP]
- T cell lineage commitment [IMP]
- T cell receptor V(D)J recombination [IMP]
- V(D)J recombination [IGI]
- brain development [IGI]
- cellular response to insulin stimulus [ISO]
- double-strand break repair [IMP]
- double-strand break repair via homologous recombination [IBA]
- double-strand break repair via nonhomologous end joining [IMP]
- ectopic germ cell programmed cell death [IMP]
- heart development [IGI]
- immunoglobulin V(D)J recombination [IMP]
- immunoglobulin production [ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage [IMP]
- lymphocyte differentiation [IMP]
- negative regulation of cellular senescence [ISO]
- negative regulation of protein phosphorylation [IMP]
- negative regulation of response to gamma radiation [ISO]
- peptidyl-serine phosphorylation [ISO]
- phosphorylation [IBA]
- positive regulation of apoptotic process [IMP]
- positive regulation of developmental growth [ISO]
- positive regulation of fibroblast proliferation [ISO]
- positive regulation of immune system process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- pro-B cell differentiation [IMP]
- protein destabilization [IDA]
- protein phosphorylation [IDA]
- regulation of circadian rhythm [IMP]
- response to gamma radiation [IMP]
- signal transduction involved in mitotic G1 DNA damage checkpoint [ISO]
- somitogenesis [IGI]
- spleen development [ISO]
- telomere maintenance [IMP]
- thymus development [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Artemis and nonhomologous end joining-independent influence of DNA-dependent protein kinase catalytic subunit on chromosome stability.
Deficiency in both ATM and the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is synthetically lethal in developing mouse embryos. Using mice that phenocopy diverse aspects of Atm deficiency, we have analyzed the genetic requirements for embryonic lethality in the absence of functional DNA-PKcs. Similar to the loss of ATM, hypomorphic mutations of Mre11 (Mre11(ATLD1)) led to synthetic lethality when juxtaposed ... [more]
Mol. Cell. Biol. Jan. 01, 2009; 29(2);503-14 [Pubmed: 19015239]
Throughput
- Low Throughput
Curated By
- BioGRID