PPIA
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MBD2
Gene Ontology Biological Process
- ATP-dependent chromatin remodeling [ISO]
- cellular protein complex assembly [IMP]
- maternal behavior [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- positive regulation of Wnt signaling pathway [IGI]
- positive regulation of chromatin binding [ISO]
- regulation of cell proliferation [IGI]
Gene Ontology Molecular Function- C2H2 zinc finger domain binding [ISO]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- chromatin binding [IDA, ISO]
- mRNA binding [IDA]
- methyl-CpG binding [IDA, ISO]
- nucleosomal DNA binding [ISO]
- protein domain specific binding [ISO]
- siRNA binding [IDA]
- C2H2 zinc finger domain binding [ISO]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- chromatin binding [IDA, ISO]
- mRNA binding [IDA]
- methyl-CpG binding [IDA, ISO]
- nucleosomal DNA binding [ISO]
- protein domain specific binding [ISO]
- siRNA binding [IDA]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Cyclophilin a protects Peg3 from hypermethylation and inactive histone modification.
Imprinted genes are expressed from only one of the parental alleles and are marked epigenetically by DNA methylation and histone modifications. Disruption of normal imprinting leads to abnormal embryogenesis, certain inherited diseases, and is associated with various cancers. In the context of screening for the gene(s) responsible for the alteration of phenotype in cyclophilin A knockdown (CypA-KD) P19 cells, we ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID