SMAD2
Gene Ontology Biological Process
- SMAD protein complex assembly [IDA]
- activin receptor signaling pathway [IMP]
- anterior/posterior pattern specification [ISS]
- cell fate commitment [ISS]
- common-partner SMAD protein phosphorylation [IDA]
- gastrulation [TAS]
- gene expression [TAS]
- intracellular signal transduction [ISS]
- mesoderm formation [ISS]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- negative regulation of transcription, DNA-templated [IMP]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- nodal signaling pathway [IMP]
- palate development [ISS]
- paraxial mesoderm morphogenesis [ISS]
- positive regulation of BMP signaling pathway [IMP]
- positive regulation of epithelial to mesenchymal transition [ISS]
- positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISS, TAS]
- positive regulation of transcription, DNA-templated [IDA, IMP, ISS]
- primary miRNA processing [TAS]
- regulation of binding [ISS]
- regulation of transforming growth factor beta receptor signaling pathway [IMP]
- response to cholesterol [IDA]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [IDA, IMP, TAS]
- zygotic specification of dorsal/ventral axis [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- I-SMAD binding [IPI]
- R-SMAD binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- SMAD binding [IPI]
- activating transcription factor binding [IPI]
- co-SMAD binding [IPI]
- double-stranded DNA binding [ISS]
- enhancer binding [IC]
- phosphatase binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- transforming growth factor beta receptor binding [IPI]
- transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity [IDA]
- type I transforming growth factor beta receptor binding [IPI]
- ubiquitin protein ligase binding [IPI]
- DNA binding [IDA]
- I-SMAD binding [IPI]
- R-SMAD binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- SMAD binding [IPI]
- activating transcription factor binding [IPI]
- co-SMAD binding [IPI]
- double-stranded DNA binding [ISS]
- enhancer binding [IC]
- phosphatase binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- transforming growth factor beta receptor binding [IPI]
- transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity [IDA]
- type I transforming growth factor beta receptor binding [IPI]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
BPTF
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells.
We have characterized the biological functions of the chromatin remodeling protein Bptf (Bromodomain PHD-finger Transcription Factor), the largest subunit of NURF (Nucleosome Remodeling Factor) in a mammal. Bptf mutants manifest growth defects at the post-implantation stage and are reabsorbed by E8.5. Histological analyses of lineage markers show that Bptf(-/-) embryos implant but fail to establish a functional distal visceral endoderm. ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID