BAIT
CHRM2
HM2
cholinergic receptor, muscarinic 2
GO Process (8)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
- G-protein coupled acetylcholine receptor signaling pathway [IDA]
- G-protein coupled receptor signaling pathway [TAS]
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [TAS]
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [TAS]
- nervous system development [TAS]
- phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway [TAS]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [IDA]
- response to virus [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SET
Ab1-115
SET nuclear proto-oncogene
GO Process (2)
GO Function (0)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The proto-oncogene SET interacts with muscarinic receptors and attenuates receptor signaling.
G protein-coupled receptors mediate cell responses to extracellular stimuli and likely function in the context of a larger signal transduction complex. Utilizing the third intracellular loop of a G protein-coupled receptor in glutathione S-transferase pulldown assays from rat brain lysates coupled with high sensitivity detection methods and subsequent functional studies, we report the identification of SET as a regulator of ... [more]
J. Biol. Chem. Dec. 29, 2006; 281(52);40310-20 [Pubmed: 17065150]
Throughput
- Low Throughput
Curated By
- BioGRID