BAIT
CHRM2
HM2
cholinergic receptor, muscarinic 2
GO Process (8)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
- G-protein coupled acetylcholine receptor signaling pathway [IDA]
- G-protein coupled receptor signaling pathway [TAS]
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [TAS]
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [TAS]
- nervous system development [TAS]
- phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway [TAS]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [IDA]
- response to virus [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SET
2PP2A, I2PP2A, IGAAD, IPP2A2, PHAPII, TAF-I, TAF-IBETA, RP11-216B9.3
SET nuclear proto-oncogene
GO Process (12)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- DNA replication [TAS]
- RNA metabolic process [TAS]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- mitotic cell cycle [TAS]
- negative regulation of catalytic activity [TAS]
- negative regulation of histone acetylation [TAS]
- negative regulation of neuron apoptotic process [IGI]
- negative regulation of transcription, DNA-templated [IDA]
- nucleocytoplasmic transport [NAS]
- nucleosome disassembly [TAS]
- regulation of catalytic activity [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
The proto-oncogene SET interacts with muscarinic receptors and attenuates receptor signaling.
G protein-coupled receptors mediate cell responses to extracellular stimuli and likely function in the context of a larger signal transduction complex. Utilizing the third intracellular loop of a G protein-coupled receptor in glutathione S-transferase pulldown assays from rat brain lysates coupled with high sensitivity detection methods and subsequent functional studies, we report the identification of SET as a regulator of ... [more]
J. Biol. Chem. Dec. 29, 2006; 281(52);40310-20 [Pubmed: 17065150]
Throughput
- Low Throughput
Curated By
- BioGRID