LRPPRC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FOXO1
Gene Ontology Biological Process
- blood vessel development [IMP]
- cellular response to DNA damage stimulus [IDA]
- cellular response to hyperoxia [ISO]
- cellular response to insulin stimulus [IDA]
- cellular response to nitric oxide [IDA]
- cellular response to oxidative stress [IDA]
- cellular response to starvation [ISO]
- glucose homeostasis [IDA]
- insulin receptor signaling pathway [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of canonical Wnt signaling pathway [IGI]
- negative regulation of fat cell differentiation [IMP]
- negative regulation of stress-activated MAPK cascade [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IGI]
- neuronal stem cell maintenance [IGI]
- positive regulation of apoptotic process [ISO]
- positive regulation of autophagy [ISO]
- positive regulation of gluconeogenesis [IMP]
- positive regulation of protein catabolic process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IGI, IMP, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of cell proliferation [IMP]
- regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of neural precursor cell proliferation [IGI]
- regulation of nucleic acid-templated transcription [IPI]
- regulation of reactive oxygen species metabolic process [IGI]
- regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of transcription, DNA-templated [IDA]
- transcription from RNA polymerase II promoter [IGI]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IGI]
- protein binding [IPI]
- protein phosphatase 2A binding [IDA]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding transcription factor activity [IPI]
- ubiquitin protein ligase binding [ISO]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IGI]
- protein binding [IPI]
- protein phosphatase 2A binding [IDA]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding transcription factor activity [IPI]
- ubiquitin protein ligase binding [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex.
Leigh syndrome French Canadian variant (LSFC) is an autosomal recessive neurodegenerative disorder due to mutation in the LRP130 (leucine-rich protein 130 kDa) gene. Unlike classic Leigh syndrome, the French Canadian variant spares the heart, skeletal muscle, and kidneys, but severely affects the liver. The precise role of LRP130 in cytochrome c oxidase deficiency and hepatic lactic acidosis that accompanies this ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID