PRMT5
Gene Ontology Biological Process
- circadian regulation of gene expression [IMP]
- endothelial cell activation [ISO]
- histone H4-R3 methylation [IMP]
- histone arginine methylation [IBA]
- negative regulation of cell differentiation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- peptidyl-arginine N-methylation [ISO]
- peptidyl-arginine methylation [ISO]
- peptidyl-arginine methylation, to symmetrical-dimethyl arginine [IBA, ISO]
- positive regulation of oligodendrocyte differentiation [ISO]
- protein methylation [ISO]
- regulation of DNA methylation [ISO]
- regulation of ERK1 and ERK2 cascade [ISO]
- spliceosomal snRNP assembly [ISO]
Gene Ontology Molecular Function- chromatin binding [IMP]
- core promoter sequence-specific DNA binding [IDA]
- histone-arginine N-methyltransferase activity [IBA]
- methyltransferase activity [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein-arginine omega-N symmetric methyltransferase activity [ISO]
- ribonucleoprotein complex binding [ISO]
- transcription corepressor activity [IMP]
- chromatin binding [IMP]
- core promoter sequence-specific DNA binding [IDA]
- histone-arginine N-methyltransferase activity [IBA]
- methyltransferase activity [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein-arginine omega-N symmetric methyltransferase activity [ISO]
- ribonucleoprotein complex binding [ISO]
- transcription corepressor activity [IMP]
SMARCA4
Gene Ontology Biological Process
- ATP catabolic process [IMP, ISO]
- ATP-dependent chromatin remodeling [ISO]
- DNA methylation on cytosine within a CG sequence [IMP]
- aortic smooth muscle cell differentiation [IMP]
- blastocyst growth [IMP]
- blastocyst hatching [IMP]
- blood vessel development [IMP]
- cell morphogenesis [IMP]
- chromatin remodeling [IMP, ISO]
- definitive erythrocyte differentiation [IMP]
- embryonic hindlimb morphogenesis [IMP]
- embryonic organ morphogenesis [IMP]
- epidermis morphogenesis [IMP]
- extracellular matrix organization [IMP]
- forebrain development [IMP]
- glial cell fate determination [IMP]
- heart development [IMP]
- heart trabecula formation [IGI]
- hindbrain development [IMP]
- histone H3 acetylation [IMP]
- in utero embryonic development [IMP]
- keratinocyte differentiation [IMP]
- lens fiber cell development [IMP]
- liver development [IMP]
- methylation-dependent chromatin silencing [IDA]
- negative regulation of androgen receptor signaling pathway [ISO]
- negative regulation of apoptotic process [IMP]
- negative regulation of cell growth [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of transcription, DNA-templated [ISO]
- nervous system development [IMP]
- neurogenesis [IDA]
- nucleosome assembly [TAS]
- nucleosome disassembly [ISO]
- outflow tract morphogenesis [IMP]
- pharyngeal arch artery morphogenesis [IMP]
- positive regulation by host of viral transcription [ISO]
- positive regulation of DNA binding [IGI]
- positive regulation of Wnt signaling pathway [IMP, ISO]
- positive regulation of cell differentiation [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IGI, IMP, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of cell migration [IMP]
- stem cell maintenance [IMP]
- transcription from RNA polymerase II promoter [ISO]
- vasculogenesis [IMP]
Gene Ontology Molecular Function- ATPase activity [IMP, TAS]
- DNA polymerase binding [IPI, ISO]
- DNA-dependent ATPase activity [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription coactivator activity [ISO]
- Tat protein binding [ISO]
- androgen receptor binding [ISO]
- chromatin binding [IDA, ISO]
- lysine-acetylated histone binding [ISO]
- nucleosomal DNA binding [ISO]
- p53 binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- transcription coactivator activity [ISO]
- transcription corepressor activity [ISO]
- transcription factor binding [IPI]
- ATPase activity [IMP, TAS]
- DNA polymerase binding [IPI, ISO]
- DNA-dependent ATPase activity [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription coactivator activity [ISO]
- Tat protein binding [ISO]
- androgen receptor binding [ISO]
- chromatin binding [IDA, ISO]
- lysine-acetylated histone binding [ISO]
- nucleosomal DNA binding [ISO]
- p53 binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- transcription coactivator activity [ISO]
- transcription corepressor activity [ISO]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The protein arginine methyltransferase Prmt5 is required for myogenesis because it facilitates ATP-dependent chromatin remodeling.
Skeletal muscle differentiation requires the coordinated activity of transcription factors, histone modifying enzymes, and ATP-dependent chromatin remodeling enzymes. The type II protein arginine methyltransferase Prmt5 symmetrically dimethylates histones H3 and H4 and numerous nonchromatin proteins, and prior work has implicated Prmt5 in transcriptional repression. Here we demonstrate that MyoD-induced muscle differentiation requires Prmt5. One of the first genes activated during ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SMARCA4 PRMT5 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID