BAIT

ATF4

CREB-2, CREB2, TAXREB67, TXREB

activating transcription factor 4

Alzheimer's Disease Project

GO Process (20)

GO Function (7)

GO Component (6)

Gene Ontology Biological Process

activation of signaling protein activity involved in unfolded protein response [TAS]

cellular amino acid metabolic process [TAS]

cellular protein metabolic process [TAS]

cellular response to glucose starvation [IMP]

circadian regulation of gene expression [ISS]

endoplasmic reticulum unfolded protein response [TAS]

gluconeogenesis [ISS]

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [ISS]

negative regulation of oxidative stress-induced neuron death [IGI]

positive regulation of apoptotic process [TAS]

positive regulation of neuron apoptotic process [ISS]

positive regulation of transcription from RNA polymerase I promoter [IMP]

positive regulation of transcription from RNA polymerase II promoter [IMP, ISS]

positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [IMP]

positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress [IMP, ISS]

positive regulation of transcription, DNA-templated [IDA, IMP, ISS, NAS]

positive regulation vascular endothelial growth factor production [IMP]

regulation of transcription, DNA-templated [ISS]

response to endoplasmic reticulum stress [IDA]

transcription from RNA polymerase II promoter [ISS]

Gene Ontology Molecular Function

DNA binding [IDA, ISS]
core promoter sequence-specific DNA binding [ISS]
protein binding [IPI]
sequence-specific DNA binding [IDA]
sequence-specific DNA binding RNA polymerase II transcription factor activity [IC]
sequence-specific DNA binding transcription factor activity [ISS, TAS]
transcription regulatory region DNA binding [IDA, TAS]

Gene Ontology Cellular Component

Lewy body core [IDA]

cytoplasm [IDA, ISS]

neuron projection [IDA]

nuclear periphery [IDA]

nucleoplasm [TAS]

nucleus [IDA, ISS]

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

PREY

ZNF226

zinc finger protein 226

GO Process (1)

GO Function (1)

GO Component (0)

Gene Ontology Biological Process

regulation of transcription, DNA-templated [IBA]

Gene Ontology Molecular Function

sequence-specific DNA binding transcription factor activity [IBA]

CRISPR Database HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

An atlas of combinatorial transcriptional regulation in mouse and man.

Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegner J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y

Combinatorial interactions among transcription factors are critical to directing tissue-specific gene expression. To build a global atlas of these combinations, we have screened for physical interactions among the majority of human and mouse DNA-binding transcription factors (TFs). The complete networks contain 762 human and 877 mouse interactions. Analysis of the networks reveals that highly connected TFs are broadly expressed across ... [more]

Cell Mar. 05, 2010; 140(5);744-52 [Pubmed: 20211142]

Throughput

High Throughput

Curated By

BioGRID