BAIT

EMX1

empty spiracles homeobox 1

GO Process (0)

GO Function (1)

GO Component (1)

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

PREY

TP63

AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L

tumor protein p63

Human Papilloma Virus (HPV) Project

GO Process (21)

GO Function (10)

GO Component (8)

Gene Ontology Biological Process

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [IBA]

apoptotic process [TAS]

cellular response to DNA damage stimulus [IDA]

cellular response to UV [IBA]

establishment of skin barrier [ISS]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IBA]

mitotic G1 DNA damage checkpoint [IBA]

negative regulation of cellular senescence [IMP]

negative regulation of transcription from RNA polymerase II promoter [IBA]

negative regulation of transcription, DNA-templated [IDA]

positive regulation of Notch signaling pathway [IDA]

positive regulation of cell cycle G1/S phase transition [IMP]

positive regulation of fibroblast apoptotic process [IDA]

positive regulation of osteoblast differentiation [IMP]

positive regulation of transcription from RNA polymerase II promoter [IDA]

positive regulation of transcription, DNA-templated [IDA, NAS]

protein homotetramerization [IPI]

regulation of epidermal cell division [ISS]

regulation of neuron apoptotic process [IBA]

response to X-ray [IBA]

response to gamma radiation [IBA]

Gene Ontology Molecular Function

DNA binding [NAS]
WW domain binding [IPI]
chromatin binding [IBA, IDA]
damaged DNA binding [IBA]
double-stranded DNA binding [IBA]
identical protein binding [IPI]
p53 binding [IBA]
protein binding [IPI]
sequence-specific DNA binding [IBA]
sequence-specific DNA binding transcription factor activity [IBA]

Gene Ontology Cellular Component

chromatin [IBA]

cytoplasm [IDA]

nuclear chromatin [IDA]

nucleoplasm [IDA]

nucleus [IDA, NAS]

transcription factor complex [IBA]

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

An atlas of combinatorial transcriptional regulation in mouse and man.

Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegner J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y

Combinatorial interactions among transcription factors are critical to directing tissue-specific gene expression. To build a global atlas of these combinations, we have screened for physical interactions among the majority of human and mouse DNA-binding transcription factors (TFs). The complete networks contain 762 human and 877 mouse interactions. Analysis of the networks reveals that highly connected TFs are broadly expressed across ... [more]

Cell Mar. 05, 2010; 140(5);744-52 [Pubmed: 20211142]

Throughput

High Throughput

Curated By

BioGRID