BAIT
LZTR1
BTBD29, LZTR-1, SWNTS2
leucine-zipper-like transcription regulator 1
GO Process (2)
GO Function (1)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
E2F8
E2F-8
E2F transcription factor 8
GO Process (10)
GO Function (6)
GO Component (0)
Gene Ontology Biological Process
- cell cycle comprising mitosis without cytokinesis [ISS]
- chorionic trophoblast cell differentiation [ISS]
- hepatocyte differentiation [ISS]
- negative regulation of cytokinesis [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISS]
- placenta development [ISS]
- positive regulation of DNA endoreduplication [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- sprouting angiogenesis [IMP]
- trophoblast giant cell differentiation [ISS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- core promoter binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IMP]
- transcription corepressor activity [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- core promoter binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IMP]
- transcription corepressor activity [ISS]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
An atlas of combinatorial transcriptional regulation in mouse and man.
Combinatorial interactions among transcription factors are critical to directing tissue-specific gene expression. To build a global atlas of these combinations, we have screened for physical interactions among the majority of human and mouse DNA-binding transcription factors (TFs). The complete networks contain 762 human and 877 mouse interactions. Analysis of the networks reveals that highly connected TFs are broadly expressed across ... [more]
Cell Mar. 05, 2010; 140(5);744-52 [Pubmed: 20211142]
Throughput
- High Throughput
Curated By
- BioGRID