BAIT
CTBP1
BARS, CtBP1-L, CtBP1-S, CtBP3/BARS, D4S115h, D5H4S115, D5H4S115E
C-terminal binding protein 1
GO Process (10)
GO Function (8)
GO Component (5)
Gene Ontology Biological Process
- Golgi organization [ISO]
- chromatin organization involved in regulation of transcription [ISO]
- negative regulation of histone H4 acetylation [ISO]
- negative regulation of histone acetylation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of histone deacetylation [ISO]
- regulation of cell cycle [ISO]
- transcription from RNA polymerase II promoter [ISO]
- white fat cell differentiation [IDA]
Gene Ontology Molecular Function- NAD binding [ISO]
- RNA polymerase II transcription corepressor activity [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein homodimerization activity [ISO]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI, ISO]
- NAD binding [ISO]
- RNA polymerase II transcription corepressor activity [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein homodimerization activity [ISO]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI, ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
HDAC2
D10Wsu179e, YAF1, Yy1bp, mRPD3
histone deacetylase 2
GO Process (43)
GO Function (18)
GO Component (13)
Gene Ontology Biological Process
- ATP-dependent chromatin remodeling [ISO]
- cardiac muscle cell development [IMP]
- cellular response to hydrogen peroxide [ISO]
- chromatin modification [TAS]
- circadian regulation of gene expression [IDA]
- dendrite development [IMP]
- embryonic digit morphogenesis [IGI]
- epidermal cell differentiation [IGI]
- eyelid development in camera-type eye [IGI]
- fungiform papilla formation [IGI]
- hair follicle placode formation [IGI]
- hippocampus development [IGI]
- histone H3 deacetylation [IDA, ISO]
- histone H4 deacetylation [IDA]
- histone deacetylation [IGI, ISO, TAS]
- maintenance of chromatin silencing [ISO]
- negative regulation of DNA binding [ISO]
- negative regulation of apoptotic process [IGI]
- negative regulation of canonical Wnt signaling pathway [IGI]
- negative regulation of cardiac muscle cell proliferation [IMP]
- negative regulation of dendritic spine development [ISO]
- negative regulation of intrinsic apoptotic signaling pathway [IGI]
- negative regulation of neuron projection development [IDA, ISO]
- negative regulation of peptidyl-lysine acetylation [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IGI, ISO]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- neuron differentiation [IGI]
- odontogenesis of dentin-containing tooth [IGI]
- positive regulation of cell proliferation [IGI, ISO]
- positive regulation of epithelial to mesenchymal transition [ISO]
- positive regulation of interleukin-1 production [ISO]
- positive regulation of oligodendrocyte differentiation [IGI, ISO]
- positive regulation of proteolysis [ISO]
- positive regulation of receptor biosynthetic process [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of tumor necrosis factor production [ISO]
- positive regulation of tyrosine phosphorylation of Stat3 protein [ISO]
- protein deacetylation [IDA]
- regulation of protein deacetylation [IGI]
- regulation of protein kinase B signaling [IMP]
- regulation of sarcomere organization [IMP]
Gene Ontology Molecular Function- Krueppel-associated box domain binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II repressing transcription factor binding [ISO]
- chromatin DNA binding [IDA]
- chromatin binding [IDA]
- core promoter binding [ISO]
- deacetylase activity [IDA]
- enzyme binding [IPI, ISO]
- heat shock protein binding [ISO]
- histone deacetylase activity [IDA, ISO, TAS]
- nucleosomal DNA binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein deacetylase activity [IDA, ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [ISO, TAS]
- Krueppel-associated box domain binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II repressing transcription factor binding [ISO]
- chromatin DNA binding [IDA]
- chromatin binding [IDA]
- core promoter binding [ISO]
- deacetylase activity [IDA]
- enzyme binding [IPI, ISO]
- heat shock protein binding [ISO]
- histone deacetylase activity [IDA, ISO, TAS]
- nucleosomal DNA binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein deacetylase activity [IDA, ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [ISO, TAS]
Gene Ontology Cellular Component
- ESC/E(Z) complex [ISO]
- NuRD complex [ISO]
- Sin3 complex [ISO]
- chromatin [ISO]
- cytoplasm [ISO, TAS]
- heterochromatin [IDA]
- histone deacetylase complex [TAS]
- nuclear chromatin [IDA, ISO]
- nucleus [IDA, ISO]
- protein complex [ISO]
- replication fork [IDA]
- transcription factor complex [IPI]
- transcriptional repressor complex [IPI]
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
An atlas of combinatorial transcriptional regulation in mouse and man.
Combinatorial interactions among transcription factors are critical to directing tissue-specific gene expression. To build a global atlas of these combinations, we have screened for physical interactions among the majority of human and mouse DNA-binding transcription factors (TFs). The complete networks contain 762 human and 877 mouse interactions. Analysis of the networks reveals that highly connected TFs are broadly expressed across ... [more]
Cell Mar. 05, 2010; 140(5);744-52 [Pubmed: 20211142]
Throughput
- High Throughput
Curated By
- BioGRID