PCBD1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HNF1A
Gene Ontology Biological Process
- SMAD protein signal transduction [IDA]
- bile acid and bile salt transport [IMP]
- bile acid biosynthetic process [IMP]
- blastocyst development [IMP]
- bone resorption [IGI]
- cholesterol metabolic process [IMP]
- chromatin remodeling [IMP]
- embryonic limb morphogenesis [IGI]
- endocrine pancreas development [IMP]
- fatty acid biosynthetic process [IMP]
- fatty acid transport [IMP]
- glucose homeostasis [IDA, IMP, ISO]
- glucose import [IDA, ISO]
- heme biosynthetic process [IMP]
- insulin secretion [IMP, ISO]
- liver development [IMP]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- paraxial mesoderm formation [IGI]
- placenta development [IGI]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- positive regulation of transcription initiation from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [IDA, IMP, ISO]
- protein localization [IMP]
- regulation of Wnt signaling pathway [IGI]
- regulation of hormone secretion [IMP]
- regulation of insulin secretion [IMP]
- regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- regulation of transcription, DNA-templated [IMP]
- renal glucose absorption [IDA, ISO]
- reproductive structure development [IMP]
- response to glucose [IMP]
- response to oxidative stress [IMP]
- reverse cholesterol transport [IMP]
- transcription from RNA polymerase II promoter [IDA, ISO]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- double-stranded DNA binding [ISO]
- protein binding [IPI]
- protein dimerization activity [IPI, ISO]
- protein heterodimerization activity [IPI, ISO]
- protein homodimerization activity [IPI, ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, IMP, ISO]
- transcription cofactor binding [ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- double-stranded DNA binding [ISO]
- protein binding [IPI]
- protein dimerization activity [IPI, ISO]
- protein heterodimerization activity [IPI, ISO]
- protein homodimerization activity [IPI, ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, IMP, ISO]
- transcription cofactor binding [ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
An atlas of combinatorial transcriptional regulation in mouse and man.
Combinatorial interactions among transcription factors are critical to directing tissue-specific gene expression. To build a global atlas of these combinations, we have screened for physical interactions among the majority of human and mouse DNA-binding transcription factors (TFs). The complete networks contain 762 human and 877 mouse interactions. Analysis of the networks reveals that highly connected TFs are broadly expressed across ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PCBD1 HNF1A | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID