BAIT
EPAS1
HIF-2alpha, HIF2A, HLF, HRF, MOP2, bHLHe73
endothelial PAS domain protein 1
GO Process (21)
GO Function (7)
GO Component (3)
Gene Ontology Biological Process
- angiogenesis [IMP]
- blood vessel remodeling [IMP]
- cell differentiation [IGI]
- cell maturation [IMP]
- cellular response to hypoxia [ISO]
- embryonic placenta development [IGI]
- erythrocyte differentiation [IMP]
- hemopoiesis [IMP]
- iron ion homeostasis [IGI]
- lung development [IMP]
- mitochondrion organization [IMP]
- myoblast fate commitment [IMP]
- norepinephrine metabolic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- regulation of heart rate [IMP]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [IDA, IGI, IMP]
- response to hypoxia [IMP, ISO]
- response to oxidative stress [IGI, IMP]
- surfactant homeostasis [IMP]
- transcription from RNA polymerase II promoter [IDA]
- visual perception [IMP]
Gene Ontology Molecular Function- DNA binding [IDA, IGI, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- histone acetyltransferase binding [ISO]
- protein heterodimerization activity [IPI, ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [IPI, ISO]
- DNA binding [IDA, IGI, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- histone acetyltransferase binding [ISO]
- protein heterodimerization activity [IPI, ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [IPI, ISO]
Mus musculus
PREY
VHL
Vhlh
von Hippel-Lindau tumor suppressor
GO Process (19)
GO Function (5)
GO Component (12)
Gene Ontology Biological Process
- NLS-bearing protein import into nucleus [IMP]
- angiogenesis [IMP]
- blood vessel endothelial cell migration [IMP]
- extracellular matrix organization [IMP]
- negative regulation of thymocyte apoptotic process [IMP]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [ISO]
- neuron differentiation [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- proteasomal protein catabolic process [IMP]
- protein catabolic process [IMP]
- protein heterooligomerization [ISO]
- protein transport [IDA]
- protein ubiquitination [ISO]
- regulation of apoptotic signaling pathway [IGI]
- regulation of catecholamine metabolic process [ISO]
- regulation of thymocyte apoptotic process [IGI]
- regulation of transcription, DNA-templated [ISO]
- response to hypoxia [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
An atlas of combinatorial transcriptional regulation in mouse and man.
Combinatorial interactions among transcription factors are critical to directing tissue-specific gene expression. To build a global atlas of these combinations, we have screened for physical interactions among the majority of human and mouse DNA-binding transcription factors (TFs). The complete networks contain 762 human and 877 mouse interactions. Analysis of the networks reveals that highly connected TFs are broadly expressed across ... [more]
Cell Mar. 05, 2010; 140(5);744-52 [Pubmed: 20211142]
Throughput
- High Throughput
Curated By
- BioGRID