BAIT
HOXC4
Hox-3.5
homeobox C4
GO Process (4)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
PREY
PBX1
2310056B04Rik, D230003C07Rik, Pbx-1
pre B cell leukemia homeobox 1
GO Process (20)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- adrenal gland development [IMP]
- anterior/posterior pattern specification [IMP]
- branching involved in ureteric bud morphogenesis [IDA]
- embryonic hemopoiesis [IMP]
- embryonic limb morphogenesis [IGI]
- embryonic organ development [IMP]
- embryonic skeletal system development [IMP]
- negative regulation of neuron differentiation [IGI]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- organ morphogenesis [IMP]
- positive regulation of G2/M transition of mitotic cell cycle [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- proximal/distal pattern formation [IGI, IMP]
- regulation of cell proliferation [IMP]
- regulation of ossification [IMP]
- spleen development [IGI, IMP]
- thymus development [IMP]
- transcription from RNA polymerase II promoter [IDA]
- urogenital system development [IMP]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- sequence-specific DNA binding [IDA, IGI]
- transcription factor binding [ISO]
- DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- sequence-specific DNA binding [IDA, IGI]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
An atlas of combinatorial transcriptional regulation in mouse and man.
Combinatorial interactions among transcription factors are critical to directing tissue-specific gene expression. To build a global atlas of these combinations, we have screened for physical interactions among the majority of human and mouse DNA-binding transcription factors (TFs). The complete networks contain 762 human and 877 mouse interactions. Analysis of the networks reveals that highly connected TFs are broadly expressed across ... [more]
Cell Mar. 05, 2010; 140(5);744-52 [Pubmed: 20211142]
Throughput
- High Throughput
Curated By
- BioGRID