BAIT
IKBKG
1110037D23Rik, AI848108, AI851264, AW124339, IKK[g], NEMO, RP23-15J3.1
inhibitor of kappaB kinase gamma
GO Process (7)
GO Function (8)
GO Component (8)
Gene Ontology Biological Process
- B cell homeostasis [IMP]
- activation of NF-kappaB-inducing kinase activity [IDA]
- cellular response to DNA damage stimulus [ISO]
- establishment of vesicle localization [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IBA, ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- K63-linked polyubiquitin binding [IDA]
- linear polyubiquitin binding [ISO]
- peroxisome proliferator activated receptor binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- ubiquitin protein ligase binding [ISO]
- K63-linked polyubiquitin binding [IDA]
- linear polyubiquitin binding [ISO]
- peroxisome proliferator activated receptor binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
TSG101
AI255943, CC2
tumor susceptibility gene 101
GO Process (13)
GO Function (7)
GO Component (8)
Gene Ontology Biological Process
- cell cycle arrest [IDA]
- cell differentiation [IDA]
- endosome to lysosome transport [ISO]
- keratinocyte differentiation [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of exosomal secretion [ISO]
- protein monoubiquitination [ISO]
- regulation of cell growth [IDA]
- regulation of extracellular vesicular exosome assembly [ISO]
- regulation of nucleic acid-templated transcription [ISO]
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [ISO]
- viral budding [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
An atlas of combinatorial transcriptional regulation in mouse and man.
Combinatorial interactions among transcription factors are critical to directing tissue-specific gene expression. To build a global atlas of these combinations, we have screened for physical interactions among the majority of human and mouse DNA-binding transcription factors (TFs). The complete networks contain 762 human and 877 mouse interactions. Analysis of the networks reveals that highly connected TFs are broadly expressed across ... [more]
Cell Mar. 05, 2010; 140(5);744-52 [Pubmed: 20211142]
Throughput
- High Throughput
Curated By
- BioGRID