BAIT
MITF
BCC2, Bhlhe32, Gsfbcc2, Vitiligo, Wh, bw, mi, vit
microphthalmia-associated transcription factor
GO Process (19)
GO Function (8)
GO Component (2)
Gene Ontology Biological Process
- Wnt signaling pathway [IDA]
- bone remodeling [IMP]
- camera-type eye development [IGI]
- canonical Wnt signaling pathway involved in negative regulation of apoptotic process [IDA]
- cell differentiation [IMP]
- cell fate commitment [IMP]
- melanocyte differentiation [IGI, IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- osteoclast differentiation [IMP]
- pigmentation [IGI, IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO, ISS]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- protein complex assembly [ISO]
- regulation of cell proliferation [IDA]
- regulation of gene expression [IMP]
- regulation of osteoclast differentiation [IGI, IMP]
- regulation of transcription, DNA-templated [IDA]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, ISO]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- chromatin binding [IDA]
- sequence-specific DNA binding [ISA]
- sequence-specific DNA binding transcription factor activity [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, ISO]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- chromatin binding [IDA]
- sequence-specific DNA binding [ISA]
- sequence-specific DNA binding transcription factor activity [IDA]
Gene Ontology Cellular Component
- nucleus [IC, IDA]
- protein complex [ISO]
Mus musculus
PREY
PAX6
1500038E17Rik, AEY11, Dey, Gsfaey11, Pax-6, Sey, RP23-431C3.1
paired box 6
GO Process (75)
GO Function (21)
GO Component (7)
Gene Ontology Biological Process
- anterior/posterior pattern specification [IGI, IMP]
- astrocyte differentiation [IMP, ISO]
- axon guidance [IMP]
- axonogenesis [IMP]
- blood vessel development [ISO]
- brain development [IMP, ISO]
- camera-type eye development [IGI, IMP]
- cell differentiation [IMP]
- cell fate commitment [IGI, IMP]
- cell fate determination [IMP]
- cerebral cortex regionalization [IMP]
- commitment of neuronal cell to specific neuron type in forebrain [IMP]
- cornea development in camera-type eye [ISO]
- dorsal/ventral axis specification [IMP]
- dorsal/ventral pattern formation [IMP]
- embryonic camera-type eye morphogenesis [IGI]
- epithelial cell development [ISO]
- establishment of mitotic spindle orientation [IMP]
- eye photoreceptor cell development [IMP]
- forebrain anterior/posterior pattern specification [IMP]
- forebrain development [IMP]
- forebrain dorsal/ventral pattern formation [IMP]
- forebrain-midbrain boundary formation [IMP]
- glucose homeostasis [ISO]
- hindbrain development [ISO]
- insulin metabolic process [ISO]
- interkinetic nuclear migration [ISO]
- iris morphogenesis [ISO]
- keratinocyte differentiation [IMP]
- lacrimal gland development [IMP]
- lens development in camera-type eye [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of neural precursor cell proliferation [IMP]
- negative regulation of neuron differentiation [IGI]
- negative regulation of protein phosphorylation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- neural crest cell migration [ISO]
- neural precursor cell proliferation [ISO]
- neuron migration [IMP, ISO]
- olfactory bulb development [ISO]
- oligodendrocyte cell fate specification [IMP]
- pallium development [IMP]
- pancreatic A cell development [IMP, ISO]
- pancreatic A cell differentiation [ISO]
- pituitary gland development [IMP]
- positive regulation of cell fate specification [ISO]
- positive regulation of epithelial cell differentiation [IMP]
- positive regulation of gene expression [IMP, ISO]
- positive regulation of glucagon secretion [ISO]
- positive regulation of neuroblast proliferation [IMP]
- positive regulation of neuron migration [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- protein localization to organelle [IMP]
- regulation of asymmetric cell division [IMP]
- regulation of cell migration [IMP]
- regulation of gene expression [IMP]
- regulation of neurogenesis [IMP, ISO]
- regulation of neuron differentiation [ISO]
- regulation of neuron projection development [ISO]
- regulation of timing of cell differentiation [IMP]
- regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment [IMP]
- regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification [IMP]
- regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification [IMP]
- regulation of transcription, DNA-templated [TAS]
- retina development in camera-type eye [IGI]
- rhombomere morphogenesis [ISO]
- salivary gland morphogenesis [IMP]
- signal transduction involved in regulation of gene expression [IDA]
- smoothened signaling pathway [IDA]
- telencephalon regionalization [IMP]
- transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- type B pancreatic cell differentiation [IMP, ISO]
Gene Ontology Molecular Function- AT DNA binding [ISO]
- DNA binding [IDA]
- HMG box domain binding [IPI]
- R-SMAD binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA, ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- chromatin binding [IDA]
- co-SMAD binding [IDA]
- double-stranded DNA binding [ISO]
- histone acetyltransferase binding [IDA]
- protein binding [IPI]
- protein kinase binding [IPI]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, TAS]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- ubiquitin protein ligase binding [IPI]
- AT DNA binding [ISO]
- DNA binding [IDA]
- HMG box domain binding [IPI]
- R-SMAD binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA, ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- chromatin binding [IDA]
- co-SMAD binding [IDA]
- double-stranded DNA binding [ISO]
- histone acetyltransferase binding [IDA]
- protein binding [IPI]
- protein kinase binding [IPI]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, TAS]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
An atlas of combinatorial transcriptional regulation in mouse and man.
Combinatorial interactions among transcription factors are critical to directing tissue-specific gene expression. To build a global atlas of these combinations, we have screened for physical interactions among the majority of human and mouse DNA-binding transcription factors (TFs). The complete networks contain 762 human and 877 mouse interactions. Analysis of the networks reveals that highly connected TFs are broadly expressed across ... [more]
Cell Mar. 05, 2010; 140(5);744-52 [Pubmed: 20211142]
Throughput
- High Throughput
Curated By
- BioGRID