BAIT
MITF
BCC2, Bhlhe32, Gsfbcc2, Vitiligo, Wh, bw, mi, vit
microphthalmia-associated transcription factor
GO Process (19)
GO Function (8)
GO Component (2)
Gene Ontology Biological Process
- Wnt signaling pathway [IDA]
- bone remodeling [IMP]
- camera-type eye development [IGI]
- canonical Wnt signaling pathway involved in negative regulation of apoptotic process [IDA]
- cell differentiation [IMP]
- cell fate commitment [IMP]
- melanocyte differentiation [IGI, IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- osteoclast differentiation [IMP]
- pigmentation [IGI, IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO, ISS]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- protein complex assembly [ISO]
- regulation of cell proliferation [IDA]
- regulation of gene expression [IMP]
- regulation of osteoclast differentiation [IGI, IMP]
- regulation of transcription, DNA-templated [IDA]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, ISO]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- chromatin binding [IDA]
- sequence-specific DNA binding [ISA]
- sequence-specific DNA binding transcription factor activity [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, ISO]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- chromatin binding [IDA]
- sequence-specific DNA binding [ISA]
- sequence-specific DNA binding transcription factor activity [IDA]
Gene Ontology Cellular Component
- nucleus [IC, IDA]
- protein complex [ISO]
Mus musculus
PREY
PIAS3
Pias3l
protein inhibitor of activated STAT 3
GO Process (4)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
An atlas of combinatorial transcriptional regulation in mouse and man.
Combinatorial interactions among transcription factors are critical to directing tissue-specific gene expression. To build a global atlas of these combinations, we have screened for physical interactions among the majority of human and mouse DNA-binding transcription factors (TFs). The complete networks contain 762 human and 877 mouse interactions. Analysis of the networks reveals that highly connected TFs are broadly expressed across ... [more]
Cell Mar. 05, 2010; 140(5);744-52 [Pubmed: 20211142]
Throughput
- High Throughput
Curated By
- BioGRID