BAIT
SREBF2
AI608257, SREBP-2, SREBP2, SREBP2gc, bHLHd2, lop13, nuc
sterol regulatory element binding factor 2
GO Process (10)
GO Function (10)
GO Component (8)
Gene Ontology Biological Process
- negative regulation of cholesterol efflux [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of cholesterol storage [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of cholesterol homeostasis [IGI]
- regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of transcription, DNA-templated [IDA]
- response to hormone [ISO]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- DNA binding [IDA]
- E-box binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- chromatin binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region DNA binding [IDA]
- DNA binding [IDA]
- E-box binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- chromatin binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region DNA binding [IDA]
Mus musculus
PREY
DMRTC2
4933432E21Rik, Dmrt7
doublesex and mab-3 related transcription factor like family C2
GO Process (6)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
An atlas of combinatorial transcriptional regulation in mouse and man.
Combinatorial interactions among transcription factors are critical to directing tissue-specific gene expression. To build a global atlas of these combinations, we have screened for physical interactions among the majority of human and mouse DNA-binding transcription factors (TFs). The complete networks contain 762 human and 877 mouse interactions. Analysis of the networks reveals that highly connected TFs are broadly expressed across ... [more]
Cell Mar. 05, 2010; 140(5);744-52 [Pubmed: 20211142]
Throughput
- High Throughput
Curated By
- BioGRID