BAIT
TRP63
AI462811, Ket, P51/P63, P63, P73l, Tp63, Trp53rp1
transformation related protein 63
GO Process (66)
GO Function (13)
GO Component (12)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [IBA]
- anatomical structure formation involved in morphogenesis [IMP]
- apoptotic process [TAS]
- cell aging [IMP]
- cell differentiation [IMP]
- cellular response to DNA damage stimulus [ISO]
- cellular response to UV [IBA]
- chromatin remodeling [IMP]
- cloacal septation [IMP]
- ectoderm and mesoderm interaction [IMP]
- embryonic limb morphogenesis [IGI, IMP]
- epidermal cell division [IMP]
- epidermis development [IMP]
- epithelial cell development [IDA, IMP]
- epithelial cell differentiation [IMP]
- establishment of planar polarity [IDA]
- establishment of skin barrier [IMP]
- female genitalia morphogenesis [IMP]
- hair follicle development [IMP]
- hair follicle morphogenesis [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IMP]
- keratinocyte differentiation [IDA]
- keratinocyte proliferation [IDA]
- mitotic G1 DNA damage checkpoint [IBA]
- morphogenesis of a polarized epithelium [IMP]
- multicellular organismal aging [IMP]
- multicellular organismal development [TAS]
- negative regulation of apoptotic process [IMP]
- negative regulation of cellular senescence [ISO]
- negative regulation of keratinocyte differentiation [IGI, IMP]
- negative regulation of mesoderm development [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
- negative regulation of transcription, DNA-templated [ISO]
- neuron apoptotic process [IMP]
- odontogenesis of dentin-containing tooth [IMP]
- organ morphogenesis [IMP]
- pattern specification process [IMP]
- polarized epithelial cell differentiation [IMP]
- positive regulation of Notch signaling pathway [IMP, ISO]
- positive regulation of apoptotic signaling pathway [IDA]
- positive regulation of cell cycle G1/S phase transition [ISO]
- positive regulation of fibroblast apoptotic process [ISO]
- positive regulation of keratinocyte proliferation [IGI]
- positive regulation of mesenchymal cell proliferation [IMP]
- positive regulation of osteoblast differentiation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IBA, IDA, IMP, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- post-anal tail morphogenesis [IMP]
- prostate gland development [IMP]
- prostatic bud formation [IMP]
- protein homotetramerization [ISO]
- proximal/distal pattern formation [IMP]
- regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- regulation of epidermal cell division [IMP]
- regulation of neuron apoptotic process [IBA]
- regulation of nucleic acid-templated transcription [IPI]
- replicative cell aging [ISO]
- response to X-ray [IBA]
- response to gamma radiation [IBA]
- skeletal system development [IMP]
- skin morphogenesis [IMP]
- smooth muscle tissue development [IMP]
- squamous basal epithelial stem cell differentiation involved in prostate gland acinus development [IMP]
- sympathetic nervous system development [IMP]
- transcription from RNA polymerase II promoter [IDA]
- urinary bladder development [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- WW domain binding [ISO]
- chromatin binding [IDA, ISO]
- damaged DNA binding [IDA]
- double-stranded DNA binding [IBA, ISO]
- identical protein binding [IPI, ISO]
- p53 binding [IBA]
- protein binding [IPI]
- protein domain specific binding [ISO]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IBA, ISO]
- transcription factor binding transcription factor activity [IPI]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- WW domain binding [ISO]
- chromatin binding [IDA, ISO]
- damaged DNA binding [IDA]
- double-stranded DNA binding [IBA, ISO]
- identical protein binding [IPI, ISO]
- p53 binding [IBA]
- protein binding [IPI]
- protein domain specific binding [ISO]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IBA, ISO]
- transcription factor binding transcription factor activity [IPI]
Gene Ontology Cellular Component
Mus musculus
PREY
TRP73
TAp73, Tp73, deltaNp73, p73, RP23-254N4.10-001
transformation related protein 73
GO Process (33)
GO Function (14)
GO Component (9)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [IBA]
- activation of MAPK activity [ISO]
- cell cycle arrest [IDA]
- cellular response to DNA damage stimulus [IMP, ISO]
- cellular response to UV [IBA]
- cerebrospinal fluid secretion [IMP]
- digestive tract morphogenesis [IMP]
- forebrain development [IMP]
- hippocampus development [IMP]
- inflammatory response [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IBA, ISO]
- mitotic G1 DNA damage checkpoint [IBA]
- negative regulation of JUN kinase activity [IDA]
- negative regulation of cardiac muscle cell proliferation [ISO]
- negative regulation of neuron apoptotic process [IDA, IMP]
- negative regulation of neuron differentiation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IBA]
- neuron development [IMP]
- positive regulation of apoptotic process [ISO]
- positive regulation of apoptotic signaling pathway [IGI]
- positive regulation of cell size [IMP]
- positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IGI]
- positive regulation of oligodendrocyte differentiation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IBA, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- post-embryonic development [IMP]
- regulation of gene expression [ISO]
- regulation of mitotic cell cycle [ISO]
- regulation of neuron apoptotic process [IGI]
- release of cytochrome c from mitochondria [IDA]
- response to X-ray [IBA]
- response to gamma radiation [IBA]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- chromatin binding [IBA]
- damaged DNA binding [IBA]
- double-stranded DNA binding [IBA]
- identical protein binding [ISO]
- p53 binding [IPI]
- protein binding [IPI]
- protein kinase binding [ISO]
- sequence-specific DNA binding [IBA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- chromatin binding [IBA]
- damaged DNA binding [IBA]
- double-stranded DNA binding [IBA]
- identical protein binding [ISO]
- p53 binding [IPI]
- protein binding [IPI]
- protein kinase binding [ISO]
- sequence-specific DNA binding [IBA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
An atlas of combinatorial transcriptional regulation in mouse and man.
Combinatorial interactions among transcription factors are critical to directing tissue-specific gene expression. To build a global atlas of these combinations, we have screened for physical interactions among the majority of human and mouse DNA-binding transcription factors (TFs). The complete networks contain 762 human and 877 mouse interactions. Analysis of the networks reveals that highly connected TFs are broadly expressed across ... [more]
Cell Mar. 05, 2010; 140(5);744-52 [Pubmed: 20211142]
Throughput
- High Throughput
Curated By
- BioGRID