BAIT
SIRT2
5730427M03Rik, SIR2L2, Sir2l
sirtuin 2
GO Process (46)
GO Function (14)
GO Component (23)
Gene Ontology Biological Process
- cellular lipid catabolic process [IMP]
- cellular response to caloric restriction [IDA]
- cellular response to epinephrine stimulus [IDA]
- cellular response to hepatocyte growth factor stimulus [ISO]
- cellular response to hypoxia [ISO]
- cellular response to molecule of bacterial origin [ISO]
- cellular response to oxidative stress [IDA]
- hepatocyte growth factor receptor signaling pathway [ISO]
- histone H3 deacetylation [IMP, ISO]
- histone H4 deacetylation [IMP, ISO]
- histone deacetylation [IGI]
- myelination in peripheral nervous system [IMP, ISO]
- negative regulation of NLRP3 inflammasome complex assembly [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of autophagy [ISO]
- negative regulation of cell proliferation [IMP, ISO]
- negative regulation of defense response to bacterium [IMP, ISO]
- negative regulation of fat cell differentiation [IMP]
- negative regulation of oligodendrocyte differentiation [ISO]
- negative regulation of oligodendrocyte progenitor proliferation [ISO]
- negative regulation of peptidyl-threonine phosphorylation [IMP]
- negative regulation of protein catabolic process [ISO]
- negative regulation of reactive oxygen species metabolic process [IMP]
- negative regulation of striated muscle tissue development [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- peptidyl-lysine deacetylation [ISO]
- phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of DNA binding [IDA]
- positive regulation of attachment of spindle microtubules to kinetochore [IMP]
- positive regulation of cell division [IMP]
- positive regulation of execution phase of apoptosis [IMP]
- positive regulation of meiosis [IMP]
- positive regulation of oocyte maturation [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein deacetylation [IDA, IMP, ISO]
- protein kinase B signaling [ISO]
- regulation of cell cycle [ISO]
- regulation of fat cell differentiation [IMP]
- regulation of myelination [IMP, ISO]
- ripoptosome assembly involved in necroptotic process [IMP]
- tubulin deacetylation [IGI, IMP, ISO]
Gene Ontology Molecular Function- NAD+ binding [ISO]
- NAD-dependent histone deacetylase activity (H4-K16 specific) [ISO]
- NAD-dependent protein deacetylase activity [ISO]
- beta-tubulin binding [IDA]
- chromatin binding [ISO]
- histone acetyltransferase binding [ISO]
- histone deacetylase activity [IMP, ISO]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- protein deacetylase activity [IDA, IMP, ISO]
- transcription factor binding [IPI, ISO]
- tubulin deacetylase activity [IMP, ISO]
- ubiquitin binding [ISO]
- zinc ion binding [ISO]
- NAD+ binding [ISO]
- NAD-dependent histone deacetylase activity (H4-K16 specific) [ISO]
- NAD-dependent protein deacetylase activity [ISO]
- beta-tubulin binding [IDA]
- chromatin binding [ISO]
- histone acetyltransferase binding [ISO]
- histone deacetylase activity [IMP, ISO]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- protein deacetylase activity [IDA, IMP, ISO]
- transcription factor binding [IPI, ISO]
- tubulin deacetylase activity [IMP, ISO]
- ubiquitin binding [ISO]
- zinc ion binding [ISO]
Gene Ontology Cellular Component
- Schmidt-Lanterman incisure [IDA, ISO]
- centriole [ISO]
- centrosome [ISO]
- chromosome [ISO]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- glial cell projection [ISO]
- juxtaparanode region of axon [ISO]
- lateral loop [ISO]
- meiotic spindle [IDA]
- microtubule [ISO]
- midbody [IDA, ISO]
- mitotic spindle [ISO]
- myelin sheath [IDA, ISO]
- myelin sheath abaxonal region [ISO]
- nuclear heterochromatin [ISO]
- nucleus [IDA, ISO]
- paranodal junction [IDA, ISO]
- paranode region of axon [ISO]
- perikaryon [IDA, ISO]
- perinuclear region of cytoplasm [IDA]
- spindle [ISO]
- terminal loop [ISO]
Mus musculus
PREY
ZBTB3
4930563M09Rik
zinc finger and BTB domain containing 3
GO Process (0)
GO Function (0)
GO Component (0)
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
An atlas of combinatorial transcriptional regulation in mouse and man.
Combinatorial interactions among transcription factors are critical to directing tissue-specific gene expression. To build a global atlas of these combinations, we have screened for physical interactions among the majority of human and mouse DNA-binding transcription factors (TFs). The complete networks contain 762 human and 877 mouse interactions. Analysis of the networks reveals that highly connected TFs are broadly expressed across ... [more]
Cell Mar. 05, 2010; 140(5);744-52 [Pubmed: 20211142]
Throughput
- High Throughput
Curated By
- BioGRID