BAIT
REST
RE1-silencing transcription factor
GO Process (26)
GO Function (12)
GO Component (5)
Gene Ontology Biological Process
- cardiac muscle cell myoblast differentiation [ISO, ISS]
- cellular response to drug [ISO, ISS]
- cellular response to electrical stimulus [ISO, ISS]
- cellular response to glucocorticoid stimulus [ISO, ISS]
- hematopoietic progenitor cell differentiation [ISO]
- histone H4 deacetylation [ISO, ISS]
- negative regulation by host of viral transcription [ISO, ISS]
- negative regulation of aldosterone biosynthetic process [IMP, ISO]
- negative regulation of amniotic stem cell differentiation [ISO, ISS]
- negative regulation of calcium ion-dependent exocytosis [IMP]
- negative regulation of cell proliferation [ISO, ISS]
- negative regulation of cortisol biosynthetic process [IMP, ISO]
- negative regulation of dense core granule biogenesis [IMP]
- negative regulation of gene expression [ISO, ISS]
- negative regulation of insulin secretion [ISO, ISS]
- negative regulation of mesenchymal stem cell differentiation [ISO]
- negative regulation of neurogenesis [ISO, ISS]
- negative regulation of neuron differentiation [IMP, ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO, NAS]
- negative regulation of transcription, DNA-templated [IDA, IMP, ISO]
- positive regulation of apoptotic process [ISO, ISS]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO, ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- potassium ion transmembrane transport [ISO, ISS]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA, ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- chromatin binding [ISO, ISS]
- core promoter binding [ISO, ISS]
- core promoter sequence-specific DNA binding [ISO]
- outward rectifier potassium channel activity [ISO, ISS]
- protein binding [IPI]
- protein complex binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISO, TAS]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [ISO, ISS]
- DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA, ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- chromatin binding [ISO, ISS]
- core promoter binding [ISO, ISS]
- core promoter sequence-specific DNA binding [ISO]
- outward rectifier potassium channel activity [ISO, ISS]
- protein binding [IPI]
- protein complex binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISO, TAS]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [ISO, ISS]
Rattus norvegicus
PREY
HDAC5
histone deacetylase 5
GO Process (27)
GO Function (13)
GO Component (7)
Gene Ontology Biological Process
- cellular response to fluid shear stress [ISO]
- cellular response to lipopolysaccharide [IEP]
- chromatin organization [TAS]
- heart development [ISO]
- histone deacetylation [ISO, NAS]
- multicellular organismal response to stress [ISO]
- negative regulation of cell migration involved in sprouting angiogenesis [ISO]
- negative regulation of myotube differentiation [ISO]
- negative regulation of osteoblast differentiation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- neuron differentiation [IEP]
- osteoblast development [ISO]
- positive regulation of neural precursor cell proliferation [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of stem cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of gene expression, epigenetic [ISO]
- regulation of myotube differentiation [ISO]
- regulation of protein binding [ISO]
- regulation of skeletal muscle fiber development [ISO]
- regulation of striated muscle cell differentiation [ISO]
- renal tubule morphogenesis [ISO]
- response to activity [IEP]
- response to cocaine [IEP, ISO]
- response to drug [IDA]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II transcription factor binding [ISO]
- chromatin binding [IDA]
- core promoter binding [ISO]
- core promoter sequence-specific DNA binding [ISO]
- histone deacetylase activity [ISO, NAS]
- protein binding [IPI]
- protein kinase C binding [ISO]
- protein kinase binding [ISO]
- repressing transcription factor binding [ISO]
- transcription corepressor activity [ISO]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II transcription factor binding [ISO]
- chromatin binding [IDA]
- core promoter binding [ISO]
- core promoter sequence-specific DNA binding [ISO]
- histone deacetylase activity [ISO, NAS]
- protein binding [IPI]
- protein kinase C binding [ISO]
- protein kinase binding [ISO]
- repressing transcription factor binding [ISO]
- transcription corepressor activity [ISO]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [ISO]
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Class II HDACs mediate CaMK-dependent signaling to NRSF in ventricular myocytes.
We recently reported that a transcriptional repressor, neuron-restrictive silencer factor (NRSF), represses expression of fetal cardiac genes, including atrial and brain natriuretic peptide (ANP and BNP), by recruiting class I histone deacetylase (HDAC) and that attenuation of NRSF-mediated repression contributes to the reactivation of fetal gene expression during cardiac hypertrophy. The molecular mechanism by which the activity of the NRSF-HDAC ... [more]
J. Mol. Cell. Cardiol. Dec. 01, 2006; 41(6);1010-22 [Pubmed: 17011572]
Throughput
- Low Throughput
Curated By
- BioGRID