E2F4
Gene Ontology Biological Process
- centriole assembly [ISS]
- gene expression [TAS]
- mitotic cell cycle [TAS]
- motile cilium assembly [ISS]
- multi-ciliated epithelial cell differentiation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISS, TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function- DNA binding [IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IC]
- protein binding [IPI]
- protein domain specific binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- DNA binding [IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IC]
- protein binding [IPI]
- protein domain specific binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
- nucleoplasm [IDA, TAS]
KMT2A
Gene Ontology Biological Process
- circadian regulation of gene expression [ISS]
- embryonic hemopoiesis [TAS]
- histone H3-K4 methylation [IDA, IMP]
- histone H3-K4 trimethylation [IDA]
- histone H4-K16 acetylation [IMP]
- positive regulation of cellular response to drug [IMP]
- positive regulation of histone H3-K4 methylation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IMP]
- positive regulation of transporter activity [IMP]
- protein complex assembly [IDA]
- regulation of histone H3-K14 acetylation [ISS]
- regulation of histone H3-K9 acetylation [ISS]
- transcription from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- AT DNA binding [NAS]
- core promoter sequence-specific DNA binding [ISS]
- histone methyltransferase activity (H3-K4 specific) [IDA, IMP]
- identical protein binding [IPI]
- lysine-acetylated histone binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [NAS]
- transcription regulatory region DNA binding [IDA]
- unmethylated CpG binding [IDA]
- zinc ion binding [IDA]
- AT DNA binding [NAS]
- core promoter sequence-specific DNA binding [ISS]
- histone methyltransferase activity (H3-K4 specific) [IDA, IMP]
- identical protein binding [IPI]
- lysine-acetylated histone binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [NAS]
- transcription regulatory region DNA binding [IDA]
- unmethylated CpG binding [IDA]
- zinc ion binding [IDA]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression.
Taspase1 was identified as the threonine endopeptidase that cleaves mixed-lineage leukemia (MLL) for proper Hox gene expression in vitro. To investigate its functions in vivo, we generated Taspase1(-/-) mice. Taspase1 deficiency results in noncleavage (nc) of MLL and MLL2 and homeotic transformations. Remarkably, our in vivo studies uncover an unexpected role of Taspase1 in the cell cycle. Taspase1(-/-) animals are ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID