POU5F1
Gene Ontology Biological Process
- BMP signaling pathway involved in heart induction [ISO]
- blastocyst growth [IGI]
- cardiac cell fate determination [ISO]
- cell fate commitment [IMP]
- cell fate commitment involved in formation of primary germ layer [ISO]
- ectodermal cell fate commitment [IDA]
- endodermal cell fate commitment [IDA]
- endodermal cell fate specification [ISO]
- germ-line stem cell maintenance [IMP]
- mRNA transcription from RNA polymerase II promoter [IDA]
- mesodermal cell fate commitment [IDA]
- negative regulation of calcium ion-dependent exocytosis [IDA]
- negative regulation of cell differentiation [IGI]
- negative regulation of gene silencing by miRNA [ISO]
- negative regulation of protein kinase B signaling [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IGI]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of SMAD protein import into nucleus [ISO]
- positive regulation of catenin import into nucleus [ISO]
- positive regulation of protein kinase B signaling [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of gene expression [ISO]
- regulation of heart induction by regulation of canonical Wnt signaling pathway [ISO]
- regulation of methylation-dependent chromatin silencing [ISO]
- regulation of transcription, DNA-templated [IDA, ISO]
- response to organic substance [IDA]
- response to retinoic acid [IDA]
- somatic stem cell maintenance [ISO]
- stem cell differentiation [IDA]
- stem cell maintenance [IMP]
- transcription from RNA polymerase II promoter [IDA, ISO]
- trophectodermal cell differentiation [IGI]
Gene Ontology Molecular Function- DNA binding [IDA, IGI, ISO]
- HMG box domain binding [ISO]
- POU domain binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II transcription coactivator activity [ISO]
- chromatin binding [IDA]
- miRNA binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription corepressor activity [IDA]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [IDA, ISO]
- ubiquitin protein ligase binding [IPI, ISO]
- DNA binding [IDA, IGI, ISO]
- HMG box domain binding [ISO]
- POU domain binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II transcription coactivator activity [ISO]
- chromatin binding [IDA]
- miRNA binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription corepressor activity [IDA]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [IDA, ISO]
- ubiquitin protein ligase binding [IPI, ISO]
MTA3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
An Oct4-centered protein interaction network in embryonic stem cells.
Transcription factors, such as Oct4, are critical for establishing and maintaining pluripotent cell identity. Whereas the genomic locations of several pluripotency transcription factors have been reported, the spectrum of their interaction partners is underexplored. Here, we use an improved affinity protocol to purify Oct4-interacting proteins from mouse embryonic stem cells (ESCs). Subsequent purification of Oct4 partners Sall4, Tcfcp2l1, Dax1, and ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| POU5F1 MTA3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 674370 | |
| POU5F1 MTA3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | 471802 |
Curated By
- BioGRID