BAIT
JARID2
Jmj, jumonji
jumonji, AT rich interactive domain 2
GO Process (11)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
- liver development [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of histone methylation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of histone H3-K9 methylation [IDA]
- regulation of cell proliferation [IMP]
- spleen development [IMP]
- stem cell differentiation [IMP]
- thymus development [IMP]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding [IDA, TAS]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- chromatin binding [IDA]
- histone demethylase activity [IDA]
- protein binding [IPI]
- DNA binding [IDA, TAS]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- chromatin binding [IDA]
- histone demethylase activity [IDA]
- protein binding [IPI]
Gene Ontology Cellular Component
Mus musculus
PREY
THRAP3
9330151F09Rik, B230333E16Rik, Trap150, RP23-365D10.5
thyroid hormone receptor associated protein 3
GO Process (10)
GO Function (7)
GO Component (5)
Gene Ontology Biological Process
- androgen receptor signaling pathway [ISO]
- intracellular steroid hormone receptor signaling pathway [ISO]
- mRNA stabilization [ISO]
- nuclear-transcribed mRNA catabolic process [ISO]
- positive regulation of mRNA splicing, via spliceosome [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of alternative mRNA splicing, via spliceosome [ISO]
- transcription from RNA polymerase II promoter [IC]
- transcription initiation from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells.
Trimethylation on histone H3 lysine 27 (H3K27me3) by Polycomb repressive complex 2 (PRC2) regulates the balance between self-renewal and differentiation of embryonic stem cells (ESCs). The mechanisms controlling the activity and recruitment of PRC2 are largely unknown. Here we demonstrate that the founding member of the Jumonji family, JMJ (JUMONJI or JARID2), is associated with PRC2, colocalizes with PRC2 and ... [more]
Cell Dec. 24, 2009; 139(7);1303-14 [Pubmed: 20064376]
Throughput
- High Throughput
Curated By
- BioGRID