ETS1
Gene Ontology Biological Process
- PML body organization [IDA]
- cell motility [IMP]
- immune response [TAS]
- negative regulation of cell cycle [IDA, IMP]
- negative regulation of cell proliferation [TAS]
- positive regulation of cellular component movement [IMP]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of erythrocyte differentiation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of angiogenesis [IMP]
- regulation of apoptotic process [IDA]
- response to antibiotic [IDA]
- transcription from RNA polymerase II promoter [IBA, IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DAXX
Gene Ontology Biological Process
- activation of JUN kinase activity [TAS]
- androgen receptor signaling pathway [IDA]
- apoptotic process [TAS]
- chromatin remodeling [IDA]
- extrinsic apoptotic signaling pathway via death domain receptors [TAS]
- negative regulation of transcription, DNA-templated [IDA]
- nucleosome assembly [IDA]
- positive regulation of neuron death [IGI]
- positive regulation of protein kinase activity [IGI]
- positive regulation of protein phosphorylation [IGI]
- regulation of protein ubiquitination [IDA]
- regulation of transcription, DNA-templated [IDA]
Gene Ontology Molecular Function- androgen receptor binding [IPI]
- enzyme binding [IPI]
- heat shock protein binding [TAS]
- histone binding [IDA]
- p53 binding [IPI]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase activator activity [IGI]
- protein kinase binding [IPI]
- receptor signaling protein activity [TAS]
- transcription corepressor activity [IDA]
- transcription factor binding [IDA]
- ubiquitin protein ligase binding [IPI]
- androgen receptor binding [IPI]
- enzyme binding [IPI]
- heat shock protein binding [TAS]
- histone binding [IDA]
- p53 binding [IPI]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase activator activity [IGI]
- protein kinase binding [IPI]
- receptor signaling protein activity [TAS]
- transcription corepressor activity [IDA]
- transcription factor binding [IDA]
- ubiquitin protein ligase binding [IPI]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Ets-1-dependent expression of vascular endothelial growth factor receptors is activated by latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus through interaction with Daxx.
Vascular endothelial growth factor (VEGF) and its receptors are highly expressed in Kaposi's sarcoma (KS) lesion and play a key role in angiogenesis. Latency-associated nuclear antigen (LANA) of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8) has multiple functions related to viral latency and KSHV-induced oncogenesis. In this report, we have identified Daxx as a LANA-binding protein by co-immunoprecipitation analysis of HeLa cells stably ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DAXX ETS1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| ETS1 DAXX | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - | |
| ETS1 DAXX | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID