BAIT
WNT8B
wnt-8b
wingless-type MMTV integration site family, member 8b
GO Process (11)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
- canonical Wnt signaling pathway [IGI]
- commissural neuron axon guidance [IGI, IMP]
- embryonic pattern specification [IGI]
- eye development [IDA]
- eye field cell fate commitment involved in camera-type eye formation [IGI]
- forebrain development [IDA]
- forebrain neuron differentiation [IMP]
- hypothalamus development [IMP]
- negative regulation of anterior neural cell fate commitment of the neural plate by Wnt signaling pathway [IMP]
- otic placode formation [IGI, IMP]
- sensory epithelium regeneration [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Danio rerio
PREY
FZD8A
fz5, fz8a, fzc, wu:fd02c05, zg05
frizzled class receptor 8a
GO Process (6)
GO Function (2)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Danio rerio
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Early stages of zebrafish eye formation require the coordinated activity of Wnt11, Fz5, and the Wnt/beta-catenin pathway.
During regional patterning of the anterior neural plate, a medially positioned domain of cells is specified to adopt retinal identity. These eye field cells remain coherent as they undergo morphogenetic events distinct from other prospective forebrain domains. We show that two branches of the Wnt signaling pathway coordinate cell fate determination with cell behavior during eye field formation. Wnt/beta-catenin signaling ... [more]
Neuron Jul. 07, 2005; 47(1);43-56 [Pubmed: 15996547]
Throughput
- Low Throughput
Ontology Terms
- phenotype: optic primordium (ZFA:0000570) [increased size (PATO:0000586)]
Curated By
- BioGRID