ARNTL
Gene Ontology Biological Process
- circadian regulation of gene expression [IDA, IMP, ISO]
- circadian rhythm [IDA, IMP]
- negative regulation of TOR signaling [IMP]
- negative regulation of fat cell differentiation [IMP]
- negative regulation of glucocorticoid receptor signaling pathway [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- oxidative stress-induced premature senescence [IMP]
- positive regulation of canonical Wnt signaling pathway [IMP]
- positive regulation of circadian rhythm [IMP]
- positive regulation of skeletal muscle cell differentiation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IC, IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [IDA, IMP, ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
- protein import into nucleus, translocation [IDA]
- regulation of cell cycle [IMP]
- regulation of cellular senescence [IMP]
- regulation of hair cycle [ISO]
- regulation of insulin secretion [IMP]
- regulation of neurogenesis [IMP]
- regulation of protein catabolic process [IDA]
- regulation of transcription, DNA-templated [IDA, ISA]
- regulation of type B pancreatic cell development [IMP]
- response to redox state [IDA, ISO]
- spermatogenesis [IMP]
- transcription from RNA polymerase II promoter [IC]
Gene Ontology Molecular Function- DNA binding [IDA, IPI, ISO]
- E-box binding [IDA, ISO]
- Hsp90 protein binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IC]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [IDA]
- aryl hydrocarbon receptor binding [ISO]
- bHLH transcription factor binding [IPI]
- core promoter binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISA]
- transcription factor binding [ISA]
- transcription regulatory region sequence-specific DNA binding [IDA]
- DNA binding [IDA, IPI, ISO]
- E-box binding [IDA, ISO]
- Hsp90 protein binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IC]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [IDA]
- aryl hydrocarbon receptor binding [ISO]
- bHLH transcription factor binding [IPI]
- core promoter binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISA]
- transcription factor binding [ISA]
- transcription regulatory region sequence-specific DNA binding [IDA]
Gene Ontology Cellular Component
CRY2
Gene Ontology Biological Process
- circadian regulation of gene expression [IGI, IMP]
- circadian rhythm [IMP]
- entrainment of circadian clock by photoperiod [IMP]
- glucose homeostasis [IGI]
- lipid storage [IGI]
- negative regulation of circadian rhythm [IDA]
- negative regulation of glucocorticoid receptor signaling pathway [IGI]
- negative regulation of glucocorticoid secretion [IGI]
- negative regulation of phosphoprotein phosphatase activity [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [IDA, IGI, ISO]
- protein import into nucleus [IPI]
- regulation of circadian rhythm [IMP]
- response to insulin [IGI]
Gene Ontology Molecular Function- DNA binding [ISO]
- FAD binding [IDA]
- damaged DNA binding [ISO]
- kinase binding [IPI]
- nuclear hormone receptor binding [IPI]
- phosphatase binding [ISO]
- protein binding [IPI]
- protein kinase binding [IPI]
- single-stranded DNA binding [ISO]
- transcription factor binding transcription factor activity [ISO]
- transcription regulatory region sequence-specific DNA binding [IDA]
- ubiquitin binding [ISO]
- DNA binding [ISO]
- FAD binding [IDA]
- damaged DNA binding [ISO]
- kinase binding [IPI]
- nuclear hormone receptor binding [IPI]
- phosphatase binding [ISO]
- protein binding [IPI]
- protein kinase binding [IPI]
- single-stranded DNA binding [ISO]
- transcription factor binding transcription factor activity [ISO]
- transcription regulatory region sequence-specific DNA binding [IDA]
- ubiquitin binding [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The polycomb group protein EZH2 is required for mammalian circadian clock function.
We examined the importance of histone methylation by the polycomb group proteins in the mouse circadian clock mechanism. Endogenous EZH2, a polycomb group enzyme that methylates lysine 27 on histone H3, co-immunoprecipitates with CLOCK and BMAL1 throughout the circadian cycle in liver nuclear extracts. Chromatin immunoprecipitation revealed EZH2 binding and di- and trimethylation of H3K27 on both the Period 1 ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ARNTL CRY2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID