BAIT
CNOT2
CDC36, NOT2, NOT2H, HSPC131
CCR4-NOT transcription complex, subunit 2
GO Process (12)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- RNA phosphodiester bond hydrolysis, exonucleolytic [IMP]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- negative regulation of intracellular estrogen receptor signaling pathway [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [TAS]
- nuclear-transcribed mRNA poly(A) tail shortening [TAS]
- positive regulation of cytoplasmic mRNA processing body assembly [IMP]
- regulation of stem cell maintenance [IMP]
- regulation of transcription from RNA polymerase II promoter [NAS]
- transcription from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
GPS2
AMF-1
G protein pathway suppressor 2
GO Process (5)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional repression by the CNOT2 subunit of the human Ccr4-Not complex.
In eukaryotic cells, the Ccr4-Not complex can regulate mRNA metabolism at various levels. Previously, we showed that promoter targeting of the CNOT2 subunit resulted in strong repression of RNA polymerase II transcription, which was sensitive to the HDAC (histone deacetylase) inhibitor, trichostatin A [Zwartjes, Jayne, van den Berg and Timmers (2004) J. Biol. Chem. 279, 10848-10854]. In the present study, ... [more]
Biochem. J. Sep. 15, 2006; 398(3);461-7 [Pubmed: 16712523]
Throughput
- Low Throughput
Curated By
- BioGRID