DNA repair protein Rad60
GO Process (4)
GO Function (1)
GO Component (1)
Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.


Smc5-Smc6-dependent removal of cohesin from mitotic chromosomes.

Outwin EA, Irmisch A, Murray JM, O'Connell MJ

The function of the essential cohesin-related Smc5-Smc6 complex has remained elusive, though hypomorphic mutants have defects late in recombination, in checkpoint maintenance, and in chromosome segregation. Recombination and checkpoints are not essential for viability, and Smc5-Smc6-null mutants die in lethal mitoses. This suggests that the chromosome segregation defects may be the source of lethality in irradiated Smc5-Smc6 hypomorphs. We show ... [more]

Mol. Cell. Biol. Aug. 01, 2009; 29(16);4363-75 [Pubmed: 19528228]


  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)
  • phenotype: heat sensitivity (APO:0000147)

Additional Notes

  • top2-191 allele is temperature sensitive

Curated By

  • BioGRID