SMARCA4
Gene Ontology Biological Process
- ATP catabolic process [IGI]
- ATP-dependent chromatin remodeling [IDA]
- chromatin remodeling [IC, IDA]
- negative regulation of G1/S transition of mitotic cell cycle [TAS]
- negative regulation of androgen receptor signaling pathway [IMP]
- negative regulation of cell growth [IMP]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- negative regulation of transcription from RNA polymerase II promoter during mitosis [TAS]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- neural retina development [IEP]
- nucleosome disassembly [IDA]
- positive regulation by host of viral transcription [IMP]
- positive regulation of Wnt signaling pathway [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- positive regulation of transcription, DNA-templated [IMP]
- regulation of transcription from RNA polymerase II promoter [NAS]
Gene Ontology Molecular Function- DNA polymerase binding [IPI]
- DNA-dependent ATPase activity [IGI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II transcription coactivator activity [IDA]
- Tat protein binding [IPI]
- androgen receptor binding [IPI]
- lysine-acetylated histone binding [IDA]
- nucleosomal DNA binding [IDA]
- p53 binding [IPI]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- transcription coactivator activity [IMP, NAS]
- transcription corepressor activity [IDA]
- DNA polymerase binding [IPI]
- DNA-dependent ATPase activity [IGI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II transcription coactivator activity [IDA]
- Tat protein binding [IPI]
- androgen receptor binding [IPI]
- lysine-acetylated histone binding [IDA]
- nucleosomal DNA binding [IDA]
- p53 binding [IPI]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- transcription coactivator activity [IMP, NAS]
- transcription corepressor activity [IDA]
Gene Ontology Cellular Component
PAX6
Gene Ontology Biological Process
- blood vessel development [IMP]
- central nervous system development [TAS]
- cornea development in camera-type eye [IMP]
- eye development [TAS]
- glucose homeostasis [IMP]
- iris morphogenesis [IMP]
- negative regulation of neurogenesis [ISS]
- neuron fate commitment [NAS]
- organ morphogenesis [TAS]
- pancreatic A cell development [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of transcription, DNA-templated [IMP]
- protein ubiquitination [ISS]
- response to wounding [IEP]
- transcription from RNA polymerase II promoter [IMP]
- visual perception [TAS]
Gene Ontology Molecular Function- DNA binding [TAS]
- R-SMAD binding [IPI]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- histone acetyltransferase binding [ISS]
- protein binding [IPI]
- protein kinase binding [ISS]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription factor binding [ISS]
- ubiquitin-protein transferase activity [ISS]
- DNA binding [TAS]
- R-SMAD binding [IPI]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- histone acetyltransferase binding [ISS]
- protein binding [IPI]
- protein kinase binding [ISS]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription factor binding [ISS]
- ubiquitin-protein transferase activity [ISS]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Regulation of alphaA-crystallin via Pax6, c-Maf, CREB and a broad domain of lens-specific chromatin.
Pax6 and c-Maf regulate multiple stages of mammalian lens development. Here, we identified novel distal control regions (DCRs) of the alphaA-crystallin gene, a marker of lens fiber cell differentiation induced by FGF-signaling. DCR1 stimulated reporter gene expression in primary lens explants treated with FGF2 linking FGF-signaling with alphaA-crystallin synthesis. A DCR1/alphaA-crystallin promoter (including DCR2) coupled with EGFP virtually recapitulated the ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PAX6 SMARCA4 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| PAX6 SMARCA4 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | - | BioGRID | 3317698 |
Curated By
- BioGRID