BAIT
PIK3CB
1110001J02Rik, AI447572, p110beta
phosphatidylinositol 3-kinase, catalytic, beta polypeptide
GO Process (7)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- cellular calcium ion homeostasis [IMP]
- embryonic cleavage [IMP]
- homophilic cell adhesion via plasma membrane adhesion molecules [IMP]
- phosphatidylinositol phosphorylation [IMP, ISO]
- phosphatidylinositol-3-phosphate biosynthetic process [IMP, ISO]
- platelet activation [IMP]
- regulation of cell-matrix adhesion [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PTK2B
CADTK, CAKB, CAKbeta, E430023O05Rik, FADK2, FAK2, PYK2, Raftk
PTK2 protein tyrosine kinase 2 beta
GO Process (72)
GO Function (8)
GO Component (18)
Gene Ontology Biological Process
- MAPK cascade [ISO]
- actin filament organization [ISO]
- activation of Janus kinase activity [ISO]
- activation of Rac GTPase activity [ISO]
- angiogenesis [ISO]
- blood vessel endothelial cell migration [ISO]
- bone resorption [IMP]
- cell adhesion [ISO]
- cell surface receptor signaling pathway [ISO]
- cellular defense response [ISO]
- cellular response to retinoic acid [ISO]
- chemokine-mediated signaling pathway [IMP]
- epidermal growth factor receptor signaling pathway [IBA, ISO]
- focal adhesion assembly [ISO]
- innate immune response [IBA]
- integrin-mediated signaling pathway [ISO]
- ionotropic glutamate receptor signaling pathway [ISO]
- long-term synaptic potentiation [ISO]
- marginal zone B cell differentiation [IMP]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of bone mineralization [IMP]
- negative regulation of cell proliferation [ISO]
- negative regulation of muscle cell apoptotic process [ISO]
- negative regulation of myeloid cell differentiation [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of ossification [ISO]
- negative regulation of potassium ion transport [ISO]
- neuron projection development [ISO]
- oocyte maturation [ISO]
- peptidyl-tyrosine autophosphorylation [IBA, ISO]
- peptidyl-tyrosine phosphorylation [IDA, ISO]
- positive regulation of B cell chemotaxis [IMP]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of JNK cascade [ISO]
- positive regulation of JUN kinase activity [ISO]
- positive regulation of actin filament polymerization [ISO]
- positive regulation of angiogenesis [IMP]
- positive regulation of cell growth [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [IMP, ISO]
- positive regulation of cell-matrix adhesion [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of endothelial cell migration [IMP, ISO]
- positive regulation of excitatory postsynaptic membrane potential [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of nitric-oxide synthase activity [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of phosphatidylinositol 3-kinase activity [IMP]
- positive regulation of protein kinase activity [IMP, ISO]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of reactive oxygen species metabolic process [ISO]
- positive regulation of synaptic transmission, glutamatergic [ISO]
- positive regulation of translation [ISO]
- protein phosphorylation [IDA]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISO]
- regulation of actin cytoskeleton reorganization [IMP]
- regulation of cGMP biosynthetic process [IMP]
- regulation of cGMP-mediated signaling [IMP]
- regulation of calcium-mediated signaling [IMP]
- regulation of cell adhesion [IBA, ISO]
- regulation of cell shape [IMP, ISO]
- regulation of establishment of cell polarity [IMP]
- regulation of inositol trisphosphate biosynthetic process [IMP]
- regulation of macrophage chemotaxis [IMP]
- regulation of nitric oxide biosynthetic process [IMP]
- regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO]
- regulation of release of sequestered calcium ion into cytosol [IMP]
- response to hydrogen peroxide [ISO]
- sprouting angiogenesis [IMP]
- stress fiber assembly [ISO]
- tumor necrosis factor-mediated signaling pathway [ISO]
- vascular endothelial growth factor receptor signaling pathway [IMP, ISO]
Gene Ontology Molecular Function- 3-phosphoinositide-dependent protein kinase binding [ISO]
- N-methyl-D-aspartate selective glutamate receptor activity [ISO]
- calmodulin-dependent protein kinase activity [ISO]
- non-membrane spanning protein tyrosine kinase activity [IDA, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase activity [IDA]
- receptor binding [IBA]
- 3-phosphoinositide-dependent protein kinase binding [ISO]
- N-methyl-D-aspartate selective glutamate receptor activity [ISO]
- calmodulin-dependent protein kinase activity [ISO]
- non-membrane spanning protein tyrosine kinase activity [IDA, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase activity [IDA]
- receptor binding [IBA]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [ISO]
- apical dendrite [ISO]
- axon [ISO]
- cell body [ISO]
- cell cortex [ISO]
- cytoplasm [ISO]
- cytosol [ISO]
- dendrite [ISO]
- extrinsic component of cytoplasmic side of plasma membrane [IBA]
- focal adhesion [ISO]
- growth cone [ISO]
- lamellipodium [ISO]
- membrane raft [ISO]
- neuronal cell body [ISO]
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [ISO]
- postsynaptic density [ISO]
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Specific function of phosphoinositide 3-kinase beta in the control of DNA replication.
Class I(A) phosphoinositide 3-kinase (PI3K) are enzymes comprised of a p85 regulatory and a p110 catalytic subunit that induce formation of 3-polyphosphoinositides, which activate numerous downstream targets. PI3K controls cell division. Of the 2 ubiquitous PI3K isoforms, alpha has selective action in cell growth and cell cycle entry, but no specific function in cell division has been described for beta. ... [more]
Proc. Natl. Acad. Sci. U.S.A. May. 05, 2009; 106(18);7525-30 [Pubmed: 19416922]
Throughput
- Low Throughput
Curated By
- BioGRID