PRMT2
Gene Ontology Biological Process
- developmental cell growth [IMP]
- histone arginine methylation [IDA]
- histone methylation [IDA, ISO]
- leptin-mediated signaling pathway [NAS]
- methylation [NAS]
- negative regulation of G1/S transition of mitotic cell cycle [IMP]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [IMP]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- peptidyl-arginine N-methylation [IMP]
- peptidyl-arginine methylation, to asymmetrical-dimethyl arginine [IBA]
- positive regulation of apoptotic process [ISO]
- positive regulation of transcription, DNA-templated [IBA, ISO]
- regulation of androgen receptor signaling pathway [ISO]
- regulation of tyrosine phosphorylation of Stat3 protein [NAS]
- response to hypoxia [IDA]
Gene Ontology Molecular Function- androgen receptor binding [ISO]
- beta-catenin binding [IPI]
- estrogen receptor binding [ISO]
- histone methyltransferase activity [ISO]
- histone-arginine N-methyltransferase activity [IDA]
- peroxisome proliferator activated receptor binding [ISO]
- progesterone receptor binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein-arginine N-methyltransferase activity [IMP]
- protein-arginine omega-N asymmetric methyltransferase activity [IBA]
- retinoic acid receptor binding [ISO]
- thyroid hormone receptor binding [ISO]
- transcription coactivator activity [IBA, ISO]
- androgen receptor binding [ISO]
- beta-catenin binding [IPI]
- estrogen receptor binding [ISO]
- histone methyltransferase activity [ISO]
- histone-arginine N-methyltransferase activity [IDA]
- peroxisome proliferator activated receptor binding [ISO]
- progesterone receptor binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein-arginine N-methyltransferase activity [IMP]
- protein-arginine omega-N asymmetric methyltransferase activity [IBA]
- retinoic acid receptor binding [ISO]
- thyroid hormone receptor binding [ISO]
- transcription coactivator activity [IBA, ISO]
NFKBIA
Gene Ontology Biological Process
- cytoplasmic sequestering of NF-kappaB [ISO]
- cytoplasmic sequestering of transcription factor [ISO]
- lipopolysaccharide-mediated signaling pathway [IDA]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of Notch signaling pathway [IMP]
- negative regulation of lipid storage [ISO]
- negative regulation of macrophage derived foam cell differentiation [ISO]
- negative regulation of myeloid cell differentiation [IMP]
- nucleotide-binding oligomerization domain containing 1 signaling pathway [IDA]
- nucleotide-binding oligomerization domain containing 2 signaling pathway [IDA]
- positive regulation of cellular protein metabolic process [ISO]
- positive regulation of cholesterol efflux [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [IMP]
- protein import into nucleus, translocation [IDA]
- regulation of cell proliferation [IDA]
- regulation of gene expression [IMP]
- response to exogenous dsRNA [IDA]
- response to lipopolysaccharide [IDA]
- response to muramyl dipeptide [IDA]
- response to muscle stretch [IDA]
- toll-like receptor 4 signaling pathway [IDA]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Protein methyltransferase 2 inhibits NF-kappaB function and promotes apoptosis.
The protein arginine methyltransferases (PRMTs) include a family of proteins with related putative methyltransferase domains that modify chromatin and regulate cellular transcription. Although some family members, PRMT1 and PRMT4, have been implicated in transcriptional modulation or intracellular signaling, the roles of other PRMTs in diverse cellular processes have not been fully established. Here, we report that PRMT2 inhibits NF-kappaB-dependent transcription ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NFKBIA PRMT2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID