BAIT
BBS4
zgc:152964
Bardet-Biedl syndrome 4
GO Process (15)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
- Kupffer's vesicle development [IGI, IMP]
- axis elongation involved in somitogenesis [IGI, IMP]
- cilium assembly [IMP]
- convergent extension [IGI, IMP]
- convergent extension involved in gastrulation [IMP]
- determination of heart left/right asymmetry [IGI, IMP]
- determination of left/right symmetry [IGI]
- gastrulation [IMP]
- heart looping [IMP]
- intracellular transport [IMP]
- melanosome transport [IGI, IMP]
- photoreceptor cell outer segment organization [IGI, IMP]
- pigment granule aggregation in cell center [IMP]
- regulation of Notch signaling pathway [IGI, IMP]
- rhodopsin metabolic process [IGI, IMP]
Gene Ontology Cellular Component
Danio rerio
PREY
WNT5B
CHUNP6928, id:ibd5111, ppt, wnt-5, wnt5, wnt[b], wu:fk85g06, CH211-281K12.10-001
wingless-type MMTV integration site family, member 5b
GO Process (22)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- Wnt signaling pathway, calcium modulating pathway [IDA, IGI]
- ameboidal-type cell migration [IMP]
- angiogenesis [IMP]
- cell fate commitment [IBA]
- cell migration involved in gastrulation [IGI, IMP]
- chondrocyte differentiation [IMP]
- convergent extension [IGI]
- convergent extension involved in axis elongation [IGI, IMP]
- convergent extension involved in gastrulation [IGI, IMP]
- dorsal convergence [IMP]
- embryonic body morphogenesis [IMP]
- endocrine pancreas development [IMP]
- fin regeneration [IMP]
- neuromast development [IMP]
- neuron differentiation [IBA]
- otolith development [IMP]
- regulation of Wnt signaling pathway, calcium modulating pathway [IGI, IMP]
- release of sequestered calcium ion into cytosol [IDA]
- skeletal system development [IMP]
- somite development [IGI]
- thrombocyte differentiation [IMP]
- unidimensional cell growth [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Danio rerio
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response.
Primary cilia and basal bodies are evolutionarily conserved organelles that mediate communication between the intracellular and extracellular environments. Here we show that bbs1, bbs4 and mkks (also known as bbs6), which encode basal body proteins, are required for convergence and extension in zebrafish and interact with wnt11 and wnt5b. Suppression of bbs1, bbs4 and mkks transcripts results in stabilization of ... [more]
Nat. Genet. Nov. 01, 2007; 39(11);1350-60 [Pubmed: 17906624]
Throughput
- Low Throughput
Ontology Terms
- phenotype: somite (ZFA:0000155) [increased length (PATO:0000573)]
Curated By
- BioGRID